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Bio-Design and Manufacturing  2019 Vol.2 No.3 P.181-186

http://doi.org/10.1007/s42242-019-00047-6


Evaluation of L929 cell morphology on anthocyanin-containing gelatin-based hydrogel for early detection of infection


Author(s):  Ghazal Shineh, Soheila S. Kordestani, Mohammadreza Tahriri, Lobat Tayebi

Affiliation(s):  Biomaterials Department, Faculty of Biomedical EngineeringAmirkabir University of TechnologyTehranIran; more

Corresponding email(s):   mohammadreza.tahriri@marquette.edu

Key Words:  Wound healing, Hydrogel, Gelatin, Infection, Anthocyanin, pH


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Ghazal Shineh, Soheila S. Kordestani, Mohammadreza Tahriri, Lobat Tayebi. Evaluation of L929 cell morphology on anthocyanin-containing gelatin-based hydrogel for early detection of infection[J]. Journal of Zhejiang University Science D, 2019, 2(3): 181-186.

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author="Ghazal Shineh, Soheila S. Kordestani, Mohammadreza Tahriri, Lobat Tayebi",
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Abstract: 
Wounds heal through a complex process including four pHases. Any interruption or interference in healing process can prevent pHp?wd=%28wound healing%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>wound healing. pHp?wd=%28infection%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>infection is one of the most common complications preventing wounds from healing. In this study, we investigated the fibroblast cell morpHology and behavior of a pHp?wd=%28gelatin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>gelatin-based pHp?wd=%28hydrogel%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>hydrogel containing pHp?wd=%28anthocyanin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>anthocyanin to determine whether it can be used for early detection of pHp?wd=%28infection%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>infection. The experimental results ascertained that 6 h after culturing the fibroblasts, they could be well attached to the surface of the pHp?wd=%28hydrogel%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>hydrogel, and 48 h after seeding, they were spread over the surface and connected with each other. After the addition of a low dose of pHp?wd=%28anthocyanin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>anthocyanin, the vitality of the cell increased, and the results of the ATR-FTIR analysis showed that pHp?wd=%28anthocyanin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>anthocyanin could eliminate remaining glutaraldehyde free radicals. pHp?wd=%28anthocyanin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>anthocyanin also could change its color after the addition of bacterial supernatant. Thus, pHp?wd=%28hydrogel%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>hydrogels containing black carrot pHp?wd=%28anthocyanin%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>anthocyanin may be a potential therapeutic and diagnostic strategy to promote pHp?wd=%28wound healing%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>wound healing and early detection of pHp?wd=%28infection%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>infection.

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