CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
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Huawei Chen, Yi Zhang, Liwen Zhang, Xilun Ding, Deyuan Zhang. Applications of bioinspired approaches and challenges in medical devices[J]. Journal of Zhejiang University Science D, 2021, 4(1): 146-148.
@article{title="Applications of bioinspired approaches and challenges in medical devices",
author="Huawei Chen, Yi Zhang, Liwen Zhang, Xilun Ding, Deyuan Zhang",
journal="Journal of Zhejiang University Science D",
volume="4",
number="1",
pages="146-148",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-020-00103-6"
}
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%J Journal of Zhejiang University SCIENCE D
%V 4
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%P 146-148
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%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-020-00103-6
TY - JOUR
T1 - Applications of bioinspired approaches and challenges in medical devices
A1 - Huawei Chen
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A1 - Liwen Zhang
A1 - Xilun Ding
A1 - Deyuan Zhang
J0 - Journal of Zhejiang University Science D
VL - 4
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SP - 146
EP - 148
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
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DOI - 10.1007/s42242-020-00103-6
Abstract:
本观点论文聚焦仿生技术在医疗器械中的应用与挑战。发展高性能医疗设备及精准医疗产业逐渐成为我国国家战略。尤其近年来,随着医疗器械精准化发展需求日益迫切,对医疗器械、医用材料提出了相容性、抗血栓、防粘防滑等更多功能需求。如何按需设计制造出“精准化”的医用材料、生机界面及医疗系统变得尤为重要。本文综述了仿生技术在医疗器械表面功能化的应用现状与发展挑战,展望了仿生科学技术在医疗器械上的应用潜力。医疗器械包括植介入、手术器械与装备、生化检测等,涵盖面宽,其性能或功能需求多且不尽相同,比如生物材料的生理相容性、医用表面的防菌防雾、手术器械的低组织损伤等。
实际上,医疗器械操控对象为“生物”,植介入物替代对象也是“生物”,因此仿生技术势必能成为解决医疗器械精准化的可行途径。以功能化仿生表面应用于医疗器械为例,探讨了如何从众多生物表面中选取仿生表面,总结了疏水/湿润滑仿生防粘表面、强湿粘附仿生表面以及细胞组织诱导仿生结构等技术发展现状。展望了仿生科学技术在精准医疗器械上进一步拓宽应用,迫切需要发展:①自然生物认知;②生/机界面作用与功能机理;③面向多功能需求的生物材料/界面设计原理;④多材料、多级微纳结构简易制造技术;⑤服役周期内的原位测试评价技术等。
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