Full Text:   <2510>

CLC number: 

On-line Access: 2021-05-04

Received: 2020-10-24

Revision Accepted: 2021-04-05

Crosschecked: 0000-00-00

Cited: 0

Clicked: 3149

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Bio-Design and Manufacturing  2021 Vol.4 No.3 P.526-540


3D tumor model biofabrication

Author(s):  Xi Zeng, Zhiguang Guo & Weimin Liu

Affiliation(s):  Department of Biomedical Engineering, Center of Biomanufacturing for Regenerative Medicine, Binghamton University, State University of New York (SUNY), PO Box 6000, Binghamton, NY 13902, USA

Corresponding email(s):   kye@binghamton.edu

Key Words:  Tumor models, Biofabrication, Tumor spheroids, Microfluidic devices, 3D bioprinting

Share this article to: More

Xi Zeng, Zhiguang Guo & Weimin Liu. 3D tumor model biofabrication[J]. Journal of Zhejiang University Science D, 2021, 4(3): 526-540.

@article{title="3D tumor model biofabrication",
author="Xi Zeng, Zhiguang Guo & Weimin Liu",
journal="Journal of Zhejiang University Science D",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T 3D tumor model biofabrication
%A Xi Zeng
%A Zhiguang Guo & Weimin Liu
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 3
%P 526-540
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00134-7

T1 - 3D tumor model biofabrication
A1 - Xi Zeng
A1 - Zhiguang Guo & Weimin Liu
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 3
SP - 526
EP - 540
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00134-7

Animal models have been extensively used in cancer pathology studies and drug discovery. These models, however, fail to reflect the complex human tumor microenvironment and do not allow for high-throughput drug screening in more human-like physiological conditions. Three-dimensional (3D) cancer models present an alternative to automated high-throughput cancer drug discovery and oncology. In this review, we highlight recent technology innovations in building 3D tumor models that simulate the complex human tumor microenvironment and responses of patients to treatment. We discussed various biofabrication technologies, including 3D bioprinting techniques developed for characterizing tumor progression, metastasis, and response to treatment.

美国宾汉顿大学Kaiming Ye等 | 三维肿瘤模型生物制造


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE