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Bio-Design and Manufacturing  2021 Vol.4 No.4 P.902-911

http://doi.org/10.1007/s42242-021-00140-9


Fabrication ofgelatin methacryloyl hydrogel microneedles fortransdermal delivery ofmetformin indiabetic rats


Author(s):  ZhiyongZeng, GuohuaJiang, TianqiLiu, GaoSong, YanfangSun, XueyaZhang, YantingJing, MingjiaFeng, YufeiShi

Affiliation(s):  School ofMaterials Science andEngineering, Zhejiang SciTech University, Hangzhou310018, China; more

Corresponding email(s):   ghjiang_cn@zstu.edu.cn, katherineyfs@zstu.edu.cn

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ZhiyongZeng,GuohuaJiang,TianqiLiu, GaoSong,YanfangSun, XueyaZhang, YantingJing,MingjiaFeng,YufeiShi. Fabrication ofgelatin methacryloyl hydrogel microneedles fortransdermal delivery ofmetformin indiabetic rats[J]. Journal of Zhejiang University Science D, 2021, 4(4): 902-911.

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author="ZhiyongZeng,GuohuaJiang,TianqiLiu, GaoSong,YanfangSun, XueyaZhang, YantingJing,MingjiaFeng,YufeiShi",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="902-911",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00140-9"
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A1 - YanfangSun
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Abstract: 
Injection therapy for diabetes has poor patient compliance, and the painoccurring at the site of subcutaneous injections causes signifcant inconvenience to diabetic patients. In this work, to demonstrate the benefts of an alternative drug delivery technique that overcomes these issues, methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic rats. Gelatin methacryloyl microneedles (GelMA-MNs) with dif-ferent degrees of substitution were successfully prepared by a micro-molding method. The resultant GelMA-MNs exhibited excellent mechanical properties and moisture resistance. Metformin, an anti-diabetic drug, was further encapsulated into the GelMA-MNs, and its release rate could be controlled by the three-dimensional cross-linked network of microneedles, thereby exhibiting sustained drug release behaviors invitro and implying a better therapeutic efect compared with that of subcutaneous injection in diabetic rats. The drug release period could be signifcantly prolonged by improving the cross-link density of GelMA-MNs. The results of hypoglycemic efect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefts for diabetes treatment.

浙理工曾志勇、江国华等 | 制备一种甲基丙烯酸化明胶微针贴片用于调节糖尿病鼠血糖

本研究论文聚焦微针贴片的制备用于调节糖尿病鼠血糖。皮下注射导致患者耐受性差,并产生疼痛感,给糖尿病患者的日常生活带来了极大的不便。本研究设计了一种甲基丙烯酸化明胶微针(GelMA-MNs)并负载二甲双胍,用于调节糖尿病鼠血糖。采用微模板法制备了GelMA-MNs。制备的GelMA-MNs具有优异的力学性能和耐湿性能。将降糖药物二甲双胍包覆至GelMA-MNs中,其体外药物释放速率可通过GelMA的溶胀进行调控,GelMA-MNs的体外药物释放实验表现出缓释行为。通过提高GelMA-MNs的交联密度,可显著延长药物释放时间。对糖尿病鼠给予GelMA-MNs经皮治疗后,GelMA-MNs的治疗效果优于皮下注射,显示出良好的糖尿病治疗效果。

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