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Bio-Design and Manufacturing  2021 Vol.4 No.4 P.717-734

http://doi.org/10.1007/s42242-021-00142-7


Recent advances inthedevelopment ofinvitro liver models forhepatotoxicity testing


Author(s):  SimingLu, JingweiZhang, ShaLin, DanfengZheng, YanShen, JialeQin, YangyangLi, ShuqiWang

Affiliation(s):  Department ofLaboratory Medicine, The First Afliated Hospital, Zhejiang University School ofMedicine, Hangzhou310003, China; more

Corresponding email(s):   11526010@zju.edu.cn, shuqi@zju.edu.cn

Key Words:  Liver injury, Drug toxicity, 3D cultureIn vitro model


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SimingLu, JingweiZhang, ShaLin, DanfengZheng, YanShen, JialeQin, YangyangLi, ShuqiWang . Recent advances inthedevelopment ofinvitro liver models forhepatotoxicity testing[J]. Journal of Zhejiang University Science D, 2021, 4(4): 717-734.

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Abstract: 
liver injury is a common cause of drug approval withdrawal during drug development, pre-clinical research, and clinical treatment. If not properly treated, patients with severe liver injury can sufer from acute liver failure or even death. Thus, utilization of the convenient invitro hepatotoxicity assessment model for early detection of drug-induced hepatotoxicity is vital for drug development and safe personalized medication. Biomaterials (e.g., hydrogels, nanofbers, decellularized liver matrix) and bioengineering technologies (e.g., microarrays, micropatterns, 3D printing, and microfuidics) have been applied for invitro hepatotoxicity assessment models. This review summarizes the structure and functions of the liver as well as the components of invitro hepatotoxicity assessment models. In addition, it highlights the latest advances in developing hepatotoxicity models with the ultimate goal of further clinical translation.

浙大一院陆思铭等 | 体外肝毒性模型的研究进展

本综述论文聚焦体外肝毒性模型的研究进展。肝损伤是药物开发、临床前研究和临床治疗中药物被召回的常见原因。肝损伤患者如果没有得到适当治疗,会因此急性肝功能衰竭甚至死亡。因此,利用方便的体外肝毒性评估模型进行早期药物诱导的肝毒性检测,对于药物开发和个性化药物治疗至关重要。生物材料(例如水凝胶、纳米纤维和脱细胞肝脏基质)和生物工程技术(例如微阵列、3D打印和微流体技术)已应用于体外肝毒性评估模型研发。本综述总结了肝脏的结构和功能,以及体外肝毒性评估模型的分类。另外,本文突出介绍了肝毒性模型的最新进展及其临床转化。

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