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On-line Access: 2022-07-01

Received: 2021-10-12

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Crosschecked: 2022-05-06

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Bio-Design and Manufacturing  2022 Vol.5 No.3 P.607-616

http://doi.org/10.1007/s42242-022-00195-2


Recent progress on microfluidic devices with incorporated 1D nanostructures for enhanced extracellular vesicle (EV) separation


Author(s):  Yuting Xiong, Hanyue Kang, Hongzhao Zhou, Liang Ma & Xiaobin Xu

Affiliation(s):  Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Shanghai Key Lab of D&A for Metal-Functional Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China; more

Corresponding email(s):   liangma@zju.edu.cn, xiaobinxu@tongji.edu.cn

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Yuting Xiong, Hanyue Kang, Hongzhao Zhou, Liang Ma & Xiaobin Xu. Recent progress on microfluidic devices with incorporated 1D nanostructures for enhanced extracellular vesicle (EV) separation[J]. Journal of Zhejiang University Science D, 2022, 5(3): 607-616.

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Abstract: 

同济大学许晓斌等 | 关于基于一维纳米结构阵列的微流控芯片用于细胞外囊泡捕获的技术展望

本观点论文聚焦基于一维纳米结构阵列的微流控芯片用于细胞外囊泡捕获的技术展望。细胞外囊泡是细胞间交流的重要媒介,是细胞膜和细胞膜蛋白、脂质和RNA在细胞间转移的载体,也是疾病诊断的有希望的生物标志物。然而,它们固有的异质性和复杂的体液微环境给它们的分离带来了重大挑战。近年来,纳米结构集成微流控芯片的发展为细胞外囊泡的分离和检测提供了一个新的方式。纳米阵列结构具有较大的比表面积,可以提供更多的生物分子结合位点,并具有独特的流体阻隔作用,从而大大提高细胞外囊泡的捕获效率、纯度和灵敏度。本文回顾了近年来基于一维纳米结构阵列的微流控芯片在加强细胞外囊泡分离上取得的进展,按照一维纳米棒、纳米线阵列和三维纳米结构的分类进行展开,并讨论了它们的工作机制(物理和化学)和优缺点。这些新兴技术有望在未来成为疾病诊断的有力工具。

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