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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
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Deep brain implantable microelectrode arrays for detection and functional localization of the subthalamic nucleus in rats with Parkinsons disease
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Luyi Jing, Zhaojie Xu, Penghui Fan, Botao Lu, Fan Mo, Ruilin Hu, Wei Xu, Jin Shan, Qianli Jia, Yuxin Zhu, Yiming Duan, Mixia Wang, Yirong Wu & Xinxia Cai. Deep brain implantable microelectrode arrays for detection and functional localization of the subthalamic nucleus in rats with Parkinsons disease[J]. Journal of Zhejiang University Science D, 2024, 7(4): 439-452.
@article{title="Deep brain implantable microelectrode arrays for detection
and functional localization of the subthalamic nucleus in rats
with Parkinsons disease",
author="Luyi Jing, Zhaojie Xu, Penghui Fan, Botao Lu, Fan Mo, Ruilin Hu, Wei Xu, Jin Shan, Qianli Jia, Yuxin Zhu, Yiming Duan, Mixia Wang, Yirong Wu & Xinxia Cai",
journal="Journal of Zhejiang University Science D",
volume="7",
number="4",
pages="439-452",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-023-00266-y"
}
%0 Journal Article
%T Deep brain implantable microelectrode arrays for detection
and functional localization of the subthalamic nucleus in rats
with Parkinsons disease
%A Luyi Jing
%A Zhaojie Xu
%A Penghui Fan
%A Botao Lu
%A Fan Mo
%A Ruilin Hu
%A Wei Xu
%A Jin Shan
%A Qianli Jia
%A Yuxin Zhu
%A Yiming Duan
%A Mixia Wang
%A Yirong Wu & Xinxia Cai
%J Journal of Zhejiang University SCIENCE D
%V 7
%N 4
%P 439-452
%@ 1869-1951
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-023-00266-y
TY - JOUR
T1 - Deep brain implantable microelectrode arrays for detection
and functional localization of the subthalamic nucleus in rats
with Parkinsons disease
A1 - Luyi Jing
A1 - Zhaojie Xu
A1 - Penghui Fan
A1 - Botao Lu
A1 - Fan Mo
A1 - Ruilin Hu
A1 - Wei Xu
A1 - Jin Shan
A1 - Qianli Jia
A1 - Yuxin Zhu
A1 - Yiming Duan
A1 - Mixia Wang
A1 - Yirong Wu & Xinxia Cai
J0 - Journal of Zhejiang University Science D
VL - 7
IS - 4
SP - 439
EP - 452
%@ 1869-1951
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-023-00266-y
Abstract: The subthalamic nucleus (STN) is considered the best target for deep brain stimulation treatments of Parkinsons disease
(PD). It is difficult to localize the STN due to its small size and deep location. Multichannel microelectrode arrays (MEAs) can
rapidly and precisely locate the STN, which is important for precise stimulation. In this paper, 16-channel MEAs modified with
multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (MWCNT/PEDOT:PSS) nanocomposites were designed and fabricated, and the accurate and rapid identification of the STN in PD rats was performed using
detection sites distributed at different brain depths. These results showed that nuclei in 6-hydroxydopamine hydrobromide
(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned brains. In addition, the MEA simultaneously
acquired neural signals from both the STN and the upper or lower boundary nuclei of the STN. Moreover, higher values
of spike firing rate, spike amplitude, local field potential (LFP) power, and beta oscillations were detected in the STN of
the 6-OHDA-lesioned brain, and may therefore be biomarkers of STN localization. Compared with the STNs of unlesioned
brains, the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta
band of 6-OHDA-lesioned brains. This may be a cause of sleep and motor disorders associated with PD. Overall, this work
describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.
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