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Bio-Design and Manufacturing  2024 Vol.7 No.4 P.428-438

http://doi.org/10.1007/s42242-024-00294-2


A crosstalk-free dual-mode sweat sensing system for naked-eye sweat loss quantification via changes in structural reflectance


Author(s):  Bowen Zhong, Hao Xu, Xiaokun Qin, Lingchen Liu, Hailong Wang & Lili Wang

Affiliation(s):  State Key Laboratory for Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China; more

Corresponding email(s):   haoxu19@semi.ac.cn, liliwang@semi.ac.cn

Key Words:  Sweat loss sensor Microfluidic design Structural reflectance Dual-mode integration Crosstalk-free


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Bowen Zhong, Hao Xu, Xiaokun Qin, Lingchen Liu, Hailong Wang & Lili Wang. A crosstalk-free dual-mode sweat sensing system for naked-eye sweat loss quantification via changes in structural reflectance[J]. Journal of Zhejiang University Science D, 2024, 7(4): 428-438.

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Abstract: 
Sweat loss monitoring is important for understanding the bodys thermoregulation and hydration status, as well as for comprehensive sweat analysis. Despite recent advances, developing a low-cost, scalable, and universal method for the fabrication of colorimetric microfluidics designed for sweat loss monitoring remains challenging. In this study, we propose a novel laserengraved surface roughening strategy for various flexible substrates. This process permits the construction of microchannels that show distinct structural reflectance changes before and after sweat filling. By leveraging these unique optical properties, we have developed a fully laser-engraved microfluidic device for the quantification of naked-eye sweat loss. This sweat loss sensor is capable of a volume resolution of 0.5 L and a total volume capacity of 11 L, and can be customized to meet different performance requirements. Moreover, we report the development of a crosstalk-free dual-mode sweat microfluidic system that integrates an Ag/AgCl chloride sensor and a matching wireless measurement flexible printed circuit board. This integrated system enables the real-time monitoring of colorimetric sweat loss signals and potential ion concentration signals without crosstalk. Finally, we demonstrate the potential practical use of this microfluidic sweat loss sensor and its integrated system for sports medicine via on-body studies.

中国科学院半导体研究所王丽丽团队 | 无串扰双模态汗液传感集成系统通过结构反射率变化直观定量汗液的流失

本研究论文提出了一种可用于各种柔性基材的新型激光雕刻表面粗糙化策略。该加工方法可构建在汗液填充前后显示出明显的结构反射率变化的微流道。通过利用这些独特的光学特性改变,我们开发了一种完全激光雕刻的微流体装置,用于裸眼量化汗液流失。该汗液流失传感器的体积分辨率为0.5 μL,总体积容量为11 μL,并且可以个性化定制以满足不同的性能需求。基于此,本文报道了一种无串扰双模态汗液微流体系统,该系统集成了 Ag/AgCl 氯离子传感器及其匹配的无线测量柔性印刷电路板。该集成系统能够实时监测汗液流失比色信号和离子浓度电压信号,且这种双模态读数不会产生串扰。最后,我们通过体表佩戴运动排汗研究,揭示了人体汗液氯离子浓度与出汗率之间的正相关性,展示了这种微流控汗液流失传感器及其集成系统在运动医学中的潜在用途价值。

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