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Bio-Design and Manufacturing  2024 Vol.7 No.4 P.476-516

http://doi.org/10.1007/s42242-024-00297-z


Recent advances and innovations in the design and fabrication of wearable flexible biosensors and human health monitoring systems based on conjugated polymers


Author(s):  Vinh Van Tran, Viet-Duc Phung & Daeho Lee

Affiliation(s):  Department of Mechanical Engineering, Gachon University, Seongnam 13120, Republic of Korea; more

Corresponding email(s):   vanvinhkhmtk30@gmail.com, dhl@gachon.ac.kr

Key Words:  Conjugated polymers · Wearable biosensors · E-skin electronics · Implantable biosensors · Conductive polymer hydrogels


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Vinh Van Tran, Viet-Duc Phung & Daeho Lee. Recent advances and innovations in the design and fabrication of wearable flexible biosensors and human health monitoring systems based on conjugated polymers[J]. Journal of Zhejiang University Science D, 2024, 7(4): 476-516.

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Abstract: 
Wearable biosensors have received great interest as patient-friendly diagnostic technologies because of their high flexibility and conformability. The growing research and utilization of novel materials in designing wearable biosensors have accelerated the development of point-of-care sensing platforms and implantable biomedical devices in human health care. Among numerous potential materials, conjugated polymers (CPs) are emerging as ideal choices for constructing high-performance wearable biosensors because of their outstanding conductive and mechanical properties. Recently, CPs have been extensively incorporated into various wearable biosensors to monitor a range of target biomolecules. However, fabricating highly reliable CP-based wearable biosensors for practical applications remains a significant challenge, necessitating novel developmental strategies for enhancing the viability of such biosensors. Accordingly, this review aims to provide consolidated scientific evidence by summarizing and evaluating recent studies focused on designing and fabricating CP-based wearable biosensors, thereby facilitating future research. Emphasizing the superior properties and benefits of CPs, this review aims to clarify their potential applicability within this field. Furthermore, the fundamentals and main components of CP-based wearable biosensors and their sensing mechanisms are discussed in detail. The recent advancements in CP nanostructures and hybridizations for improved sensing performance, along with recent innovations in next-generation wearable biosensors are highlighted. CPbased wearable biosensors have been—and will continue to be—an ideal platform for developing effective and user-friendly diagnostic technologies for human health monitoring.

韩国嘉泉大学Daeho Lee等 | 基于共轭聚合物的可穿戴柔性生物传感器和人体健康监测系统的设计和制造进展

本综述论文聚焦基于共轭聚合物的可穿戴柔性生物传感器和人体健康监测系统的设计和制造进展。可穿戴生物传感器作为对患者友好的诊断技术,因其高柔性和舒适性,受到了极大的关注。在可穿戴生物传感器设计中,新型材料的不断研究和应用加速了医疗保健中床旁检测平台和植入式生物医学设备的发展。在众多潜在材料中,共轭聚合物(CPs)因其出色的导电性和机械性能,正在成为构建高性能可穿戴生物传感器的理想选择。最近,CPs已被广泛集成到各种可穿戴生物传感器中,以监测一系列目标生物分子。然而,为实际应用制造可靠的基于CP的可穿戴生物传感器仍然是一个重大挑战,需要新的发展策略来增强这类生物传感器的可行性。因此,本综述旨在通过总结和评估近期基于CP的可穿戴生物传感器设计和制造的研究,提供综合的科学证据,以推动未来的研究工作。本综述强调了CPs的卓越性能和优势,并旨在明确它们在该领域的潜在应用前景。此外,本文详细讨论了基于CP的可穿戴生物传感器的基本原理、主要组成部分及其传感机制。强调了CP纳米结构和杂化在提高传感性能方面的最新进展,以及下一代可穿戴生物传感器的最新创新。我们相信,基于CP的可穿戴生物传感器一直是并将继续是开发有效且用户友好的人类健康监测诊断技术的理想平台。

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