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On-line Access: 2024-08-27
Received: 2023-10-17
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Rapid Fabrication of Modular 3D Paper-Based Microfluidic Chips using Projection-Based 3D Printing
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Mingjun Xie,Zexin Fu, Chunfei Lu, Sufan Wu, Lei Pan , Yong He, Yi Sun, Ji Wang. Rapid Fabrication of Modular 3D Paper-Based Microfluidic Chips using Projection-Based 3D Printing[J]. Journal of Zhejiang University Science D, 2024, 7(5): 611-623.
@article{title="Rapid Fabrication of Modular 3D Paper-Based Microfluidic Chips
using Projection-Based 3D Printing",
author="Mingjun Xie,Zexin Fu, Chunfei Lu, Sufan Wu, Lei Pan , Yong He, Yi Sun, Ji Wang",
journal="Journal of Zhejiang University Science D",
volume="7",
number="5",
pages="611-623",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-024-00298-y"
}
%0 Journal Article
%T Rapid Fabrication of Modular 3D Paper-Based Microfluidic Chips
using Projection-Based 3D Printing
%A Mingjun Xie
%A Zexin Fu
%A Chunfei Lu
%A Sufan Wu
%A Lei Pan
%A Yong He
%A Yi Sun
%A Ji Wang
%J Journal of Zhejiang University SCIENCE D
%V 7
%N 5
%P 611-623
%@ 1869-1951
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-024-00298-y
TY - JOUR
T1 - Rapid Fabrication of Modular 3D Paper-Based Microfluidic Chips
using Projection-Based 3D Printing
A1 - Mingjun Xie
A1 - Zexin Fu
A1 - Chunfei Lu
A1 - Sufan Wu
A1 - Lei Pan
A1 - Yong He
A1 - Yi Sun
A1 - Ji Wang
J0 - Journal of Zhejiang University Science D
VL - 7
IS - 5
SP - 611
EP - 623
%@ 1869-1951
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-024-00298-y
Abstract: Paper-based microchips have different advantages, such as better biocompatibility,
simple production, and easy handling, which makes them promising candidates for clinical
diagnosis and other fields. This study describes a method developed to fabricate modular
three-dimensional (3D) paper-based microfluidic chips based on projection-based 3D printing
(PBP) technology. A series of two-dimensional (2D) paper-based microfluidic modules was
designed and fabricated. After evaluating the effect of exposure time on the accuracy of the
flow channel, the resolution of this channel was experimentally analyzed. Furthermore,
several 3D paper-based microfluidic chips were assembled based on the 2D ones using
different methods, with good channel connectivity. Scaffold-based 2D and hydrogel-based 3D
cell culture systems based on 3D paper-based microfluidic chips were verified to be feasible.
Furthermore, by combining extrusion 3D bioprinting technology and the proposed 3D
paper-based microfluidic chips, multiorgan microfluidic chips were established by directly
printing 3D hydrogel structures on 3D paper-based microfluidic chips, confirming that the
prepared modular 3D paper-based microfluidic chip is potentially applicable in various
biomedical applications.
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