Full Text:   <256>

CLC number: 

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 0000-00-00

Cited: 0

Clicked: 354

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Bio-Design and Manufacturing  2024 Vol.7 No.4 P.399-412

http://doi.org/10.1007/s42242-024-00299-x


A drug-loaded flexible substrate improves the performance of conformal cortical electrodes


Author(s):  Rongrong Qin, Tian Li, Yifu Tan, Fanqi Sun, Yuhao Zhou, Ronghao Lv, Xiaoli You, Bowen Ji, Peng Li & Wei Huang

Affiliation(s):  Frontiers Science Center for Flexible Electronics (FSCFE), Xi’an Institute of Flexible Electronics (IFE) and Xi’an Institute of Biomedical Materials & Engineering (IBME), Northwestern Polytechnical University, Xi’an 710072, China; more

Corresponding email(s):   bwji@nwpu.edu.cn, iampli@nwpu.edu.cn, vc@nwpu.edu.cn

Key Words:  Antibacterial · Anti-inflammatory · Drug loading · Cortical electrodes · Bacterial cellulose hydrogel


Share this article to: More

Rongrong Qin, Tian Li, Yifu Tan, Fanqi Sun, Yuhao Zhou, Ronghao Lv, Xiaoli You, Bowen Ji, Peng Li & Wei Huang. A drug-loaded flexible substrate improves the performance of conformal cortical electrodes[J]. Journal of Zhejiang University Science D, 2024, 7(4): 399-412.

@article{title="A drug-loaded flexible substrate improves the performance of conformal cortical electrodes",
author="Rongrong Qin, Tian Li, Yifu Tan, Fanqi Sun, Yuhao Zhou, Ronghao Lv, Xiaoli You, Bowen Ji, Peng Li & Wei Huang",
journal="Journal of Zhejiang University Science D",
volume="7",
number="4",
pages="399-412",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-024-00299-x"
}

%0 Journal Article
%T A drug-loaded flexible substrate improves the performance of conformal cortical electrodes
%A Rongrong Qin
%A Tian Li
%A Yifu Tan
%A Fanqi Sun
%A Yuhao Zhou
%A Ronghao Lv
%A Xiaoli You
%A Bowen Ji
%A Peng Li & Wei Huang
%J Journal of Zhejiang University SCIENCE D
%V 7
%N 4
%P 399-412
%@ 1869-1951
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-024-00299-x

TY - JOUR
T1 - A drug-loaded flexible substrate improves the performance of conformal cortical electrodes
A1 - Rongrong Qin
A1 - Tian Li
A1 - Yifu Tan
A1 - Fanqi Sun
A1 - Yuhao Zhou
A1 - Ronghao Lv
A1 - Xiaoli You
A1 - Bowen Ji
A1 - Peng Li & Wei Huang
J0 - Journal of Zhejiang University Science D
VL - 7
IS - 4
SP - 399
EP - 412
%@ 1869-1951
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-024-00299-x


Abstract: 
Cortical electrodes are a powerful tool for the stimulation and/or recording of electrical activity in the nervous system. However, the inevitable wound caused by surgical implantation of electrodes presents bacterial infection and inflammatory reaction risks associated with foreign body exposure. Moreover, inflammation of the wound area can dramatically worsen in response to bacterial infection. These consequences can not only lead to the failure of cortical electrode implantation but also threaten the lives of patients. Herein, we prepared a hydrogel made of bacterial cellulose (BC), a flexible substrate for cortical electrodes, and further loaded antibiotic tetracycline (TC) and the anti-inflammatory drug dexamethasone (DEX) onto it. The encapsulated drugs can be released from the BC hydrogel and effectively inhibit the growth of Gram-negative and Gram-positive bacteria. Next, therapeutic cortical electrodes were developed by integrating the drug-loaded BC hydrogel and nine-channel serpentine arrays; these were used to record electrocorticography (ECoG) signals in a rat model. Due to the controlled release of TC and DEX from the BC hydrogel substrate, therapeutic cortical electrodes can alleviate or prevent symptoms associated with the bacterial infection and inflammation of brain tissue. This approach facilitates the development of drug delivery electrodes for resolving complications caused by implantable electrodes.

西北工业大学黄维院士李鹏教授吉博文副教授团队 | 抗菌抗炎脑机接口柔性电极

本研究论文聚焦侵入式脑机接口的长期稳定使用。侵入式脑机接口通过直接将电极植入到大脑的灰质或大脑皮层获取高质量的神经信号。然而, 植入电极所导致的不可避免的伤口带来了与外源性物质暴露相关的细菌感染和炎症反应风险。此外, 伤口区域的炎症可能会因细菌感染而急剧恶化。这些后果不仅会导致脑机接口信号质量的衰退甚至消失, 还可能威胁患者生命。本研究通过以可缓释药物的水凝胶为柔性基底,集成蛇形阵列,提出了一种兼具脑电信号监测和药物缓释治疗的脑机接口构建方法。基于此,以抗生素和抗炎药物为模型,本研究制备了负载四环素 (TC) 和地塞米松 (DEX) 的细菌纤维素 (BC) 水凝胶。进一步地, 通过将负载药物的BC水凝胶与九通道蛇形阵列集成, 开发了抗菌抗炎脑机接口柔性电极, 并将其用于大鼠模型中记录皮层脑电图 (ECoG) 信号。该柔性电极可与大脑皮层共形贴附, 实现高分辨率脑电信号采集。此外,负载的药物TC和DEX可以从脑机接口电极中缓慢释放, 有效抑制革兰阴性和阳性细菌的生长以及炎症反应。本研究为药物递送电极的开发以及侵入式脑机接口的长期稳定使用奠定了基础。

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE