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Bio-Design and Manufacturing  2016 Vol.-1 No.-1 P.

http://doi.org/10.1007/s42242-024-00308-z


Integrated nanoporous electroporation and sensing electrode array for total dynamic time-domain cardiomyocyte membrane resealing assessment


Author(s):  Weiqin Sheng, Ying Li, Chunlian Qin, Zhonghai Zhang, Yuxiang Pan, Zhicheng Tong, Chong Teng, Xinwei Wei

Affiliation(s):  School of Electronic Information, Hangzhou Dianzi University, Hangzhou 310018, China; more

Corresponding email(s):   shengwq@hdu.edu.cn, yingli@zcmu.edu.cn, tengchong1984@zju.edu.cn, weixinwei@zju.edu.cn

Key Words:  Nanoporous electrode array (NPEA), Electroporation, Intracellular potential recording, Cardiomyocyte, Membrane resealing


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Weiqin Sheng, Ying Li, Chunlian Qin, Zhonghai Zhang, Yuxiang Pan, Zhicheng Tong, Chong Teng, Xinwei Wei. Integrated nanoporous electroporation and sensing electrode array for total dynamic time-domain cardiomyocyte membrane resealing assessment[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .

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Abstract: 
Intracellular electrophysiological research is vital for biological and medical research. Traditional planar microelectrode arrays (MEAs) have disadvantages in recording intracellular action potentials due to the loose cellelectrode interface. To investigate intracellular electrophysiological signals with high sensitivity, electroporation was used to obtain intracellular recordings. In this study, a biosensing system based on a nanoporous electrode array (NPEA) integrating electrical perforation and signal acquisition was established to dynamically and sensitively record the intracellular potential of cardiomyocytes over a long period of time. Moreover, nanoporous electrodes can induce the protrusion of cell membranes and enhance cellelectrode interfacial coupling, thereby facilitating effective electroporation. Electrophysiological signals over the entire recording process can be quantitatively and segmentally analyzed according to the signal changes, which can equivalently reflect the dynamic evolution of the electroporated cardiomyocyte membrane. We believe that the low-cost and highperformance nanoporous biosensing platform suggested in this study can dynamically record intracellular action potential, evaluate cardiomyocyte electroporation, and provide a new strategy for investigating cardiology pharmacological science.

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