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On-line Access: 2020-08-10

Received: 2019-04-24

Revision Accepted: 2019-08-12

Crosschecked: 2020-03-03

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Chen-lei Pang

https://orcid.org/0000-0002-3167-9090

Qing Yang

https://orcid.org/0000-0001-5324-4832

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Frontiers of Information Technology & Electronic Engineering  2020 Vol.21 No.8 P.1134-1149

http://doi.org/10.1631/FITEE.1900211


Chip-based waveguides for high-sensitivity biosensing and super-resolution imaging


Author(s):  Chen-lei Pang, Xu Liu, Wei Chen, Qing Yang

Affiliation(s):  State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   qingyang@zju.edu.cn

Key Words:  Waveguide-based sensing, Waveguide-based imaging, Evanescent illumination, Frequency shifting and stitching


Chen-lei Pang, Xu Liu, Wei Chen, Qing Yang. Chip-based waveguides for high-sensitivity biosensing and super-resolution imaging[J]. Frontiers of Information Technology & Electronic Engineering, 2020, 21(8): 1134-1149.

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Abstract: 
In this review, we introduce some chip-based waveguide biosensing and imaging techniques, which significantly reduce the complexity of the entire system. These techniques use a well-confined evanescent field to interact with the surrounding materials and achieve high sensitivity sensing and high signal-to-noise ratio (SNR) super-resolution imaging. The fabrication process of these chips is simple and compatible with conventional semiconductor fabrication methods, allowing high-yield production. Combined with recently developed chip-based light sources, these techniques offer the possibility of biosensing and super-resolution imaging based on integrated circuits.

基于片上波导的超灵敏探测与超分辨成像

庞陈雷1,刘旭1,陈伟2,3,杨青1,4
1浙江大学光电科学与工程学院现代光学仪器国家重点实验室,中国杭州市,310027
2浙江大学医学院细胞生物学系,中国杭州市,310058
3浙江大学现代光学仪器国家重点实验室,感染性疾病诊治协同创新中心,中国杭州市,310058
4山西大学极端光学协同创新中心,中国太原市,030006

摘要:本综述介绍基于芯片的波导生物传感和成像技术的最新研究进展,这些技术可显著降低系统复杂度。这些技术利用波导表面的近场倏逝场与周围样品产生相互作用,实现对被检测生物分子的高灵敏探测和微纳样品的高信噪比超分辨成像。相关检测与成像波导芯片的制作过程简单,且同传统半导体加工工艺兼容,具有大规模生产应用前景。通过与近年来快速发展的片上集成光源结合,这些技术为实现片上系统集成的生物分子检测和超分辨成像提供了可能。

关键词:波导探测;波导成像;倏逝场照明;移频与频谱拼接

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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