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Bio-Design and Manufacturing  2018 Vol.1 No.1 P.97-98

10.1631/jzus.2000.0097


STUDY OF RELATION BETWEEN HYPERTENSIVE LEFT VENTRICULAR HYPERTROPHY AND NEUROCRINE FACTORS


Author(s):  GUO Hang-yuan, LU Duan

Affiliation(s):  Internal Medicine Dept. of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310016, China

Corresponding email(s): 

Key Words:  hypertension, left ventricular hypertrophy, neurohumor, ventricular premature


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GUO Hang-yuan, LU Duan. STUDY OF RELATION BETWEEN HYPERTENSIVE LEFT VENTRICULAR HYPERTROPHY AND NEUROCRINE FACTORS[J]. Journal of Zhejiang University Science D, 2018, 1(1): 97-98.

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Abstract: 
In this study of the relationship between hypertensive left ventricular hypertrophy(LVH) and neurohumor factors and ventricular arrhythmias, 180 cases were divided at random into 3 groups: 60 cases with primary hypertension and LVH(PH+LVH); 60 cases with simple hypertension(PH), and with other diseases and LVH(NPH+LVH). The results showed that 1. The excitability of the sympathetic nerve was not elevated while the activity of the vagus nerve was not significantly decreased in the patients with PH+LVH.The increased sympathetic nervous tension was correlated with the ventricular premature beat which was statistically correlated with the myocardial ischemia. 2. The patients' condition in group PH+LVH was not correlated with the levels of aldosterone and insulin and was not even positively correlated with the levels of renin and angiotensin-II. 3. The patients in group PH+LVH had high incidence of ventricular premature beat and myocardial ischemia. 4. The patients' condition in group NPH+LVH was not even positively correlated with the neurohumor factors but their heart failure was positively correlated with the levels of aldosterone, sympathetic nervous tension, myocardial ischemia and ventricular premature beat.

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Reference

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[2]Grossman, Z., Alster, Y., Shemesh, J. et al. 1994. Left ventricular mass in hypertension: Correlation with casual, exercise and ambulatory blood pressure. J Hum Hypertens, 8(10):741.

[3]Mayet, J., Shahi, M., Poulter, N.R. et al., 1995. Ventricular arrhythmias in hypertension:In which patients do they occur. J Hypertens, 13(2):269.

[4]Perloff, D., 1994. Retrospective and prospective research on hypertension related end-organ damage.J Cardiovasc Pharmacol, 24(suppl.A):SJ-5.

[5]Siche, J.P., Schwebel, C., Longere, P. et al., 1994. Left ventricular hypertrophy and blood pressure variability during rest and ambulatory monitoring in the hypertension patient. Archmal, 32(8):1305.

[6]Zhang, W.Z., Gong, L.S., 1991. Clinical evaluation of the loss of nocturnal decline of blood pressure in patients with hypertension. Chin Med Sci J, 6(suppl):34(in chinese with English abstract).

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