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Journal of Zhejiang University SCIENCE A 2000 Vol.1 No.2 P.227-228

http://doi.org/10.1631/jzus.2000.0227


THE RELATIONSHIP BETWEEN ULCER RECURRENCE AND HELICOBACTER PYLORI: A PROSPECTIVE ONE-YEAR FOLLOW-UP STUDY IN CHINA


Author(s):  SI Jian-min, JIN Yi-yi, WU Jia-guo

Affiliation(s):  Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s): 

Key Words:  H. pylori reinfection, peptic ulcer/relapse


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SI Jian-min, JIN Yi-yi, WU Jia-guo. THE RELATIONSHIP BETWEEN ULCER RECURRENCE AND HELICOBACTER PYLORI: A PROSPECTIVE ONE-YEAR FOLLOW-UP STUDY IN CHINA[J]. Journal of Zhejiang University Science A, 2000, 1(2): 227-228.

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doi="10.1631/jzus.2000.0227"
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Abstract: 
To study the relationship between ulcer recurrence and Helicobacter Pylori. 147 patients with peptic ulcer were divided into H. Pylori infected group and H.pylori uninfected group by rapid urease test, serum antibody examination and histopathology of gastric biopsy specimens. We assigned all patients to receive dual oral therapy with omeprazole 40 mg/day for 4 weeks and amoxicillin 2000 mg/day for 2 weeks. To all patients, repeated gastroscope was performed at 8 weeks and one-year after beginning therapy to record whether the ulcer was cured. Endoscopic biopsy was also performed to dertermine H.pylori status. One year later, H.pylori positive patients had a higher ulcer recurrent rate than H.pylori negative patients(23.33% vs 2.70%; P=0.001). Ulcer recurrence was closely related to H.pylori infection. H.pylori was the risk factor for ulcer relapse.

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Reference

[1]Abu-Mahfouz, M.Z., Prasad, V.M., Santogade, P., et al., 1997. Helicobactor pylori recurrence after successful eradication: 5-year follow-up in the United States. Amer J Gastroenterol, 92: 2025-2029.

[2]Fan Bihui, 1996. Effect of Helicobactor pylori eradication on peptic ulcer recurrence. Academic Journal of Nan Tong Medical College, 16: 568-570(in Chinese).

[3]Mitchell, H.M.,Hu, Pinjin, Chi Yi, et al., 1998. A low rate of reinfection following effective therapy against Helicobactor pylori in a developing nation (China). Gastroenterology,114: 256-259.

[4]NIH consensus development panel on Helicobactor pylori in peptic ulcer desease, 1994. Helicobactor pylori in peptic ulcer disease. JAMA, 272:65-69.

[5]Rene, W.M., Hulst, V.D., Rauws Erik, A.J., et al., 1997. Prevention of ulcer recurrence after eradication of Helicobactor pylori: A prospective long-term follow-up study. Gastroenterology, 113: 1082-1087.

[6]Tytgat, G.N.J., Noach, J.A., Rauws, E.A.J., 1993. Helicobactor pylori infection and duodenal ulcer disease, Gastroenterol Clin North Am,22:127-138.

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