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Journal of Zhejiang University SCIENCE A 2003 Vol.4 No.5 P.612~615

http://doi.org/10.1631/jzus.2003.0612


Effects of atorvastatin on vascular remodeling in spontaneously hypertensive rats


Author(s):  GE Chang-jiang, HU Shen-jiang, WU Yao-sen, CHEN Nai-yun

Affiliation(s):  First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   SoHu0001@hotmail.com

Key Words:  Atorvastatin, Hypertension, Vascular remodeling


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GE Chang-jiang, HU Shen-jiang, WU Yao-sen, CHEN Nai-yun. Effects of atorvastatin on vascular remodeling in spontaneously hypertensive rats[J]. Journal of Zhejiang University Science A, 2003, 4(5): 612~615.

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author="GE Chang-jiang, HU Shen-jiang, WU Yao-sen, CHEN Nai-yun",
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doi="10.1631/jzus.2003.0612"
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%A CHEN Nai-yun
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T1 - Effects of atorvastatin on vascular remodeling in spontaneously hypertensive rats
A1 - GE Chang-jiang
A1 - HU Shen-jiang
A1 - WU Yao-sen
A1 - CHEN Nai-yun
J0 - Journal of Zhejiang University Science A
VL - 4
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SP - 612
EP - 615
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2003.0612


Abstract: 
Objective: To investigate the structural changes of aorta, and evaluate the effects of atorvastatin on the remodeling of thoracic aorta in spontaneously hypertensive rats (SHR). Methods: Twelve eight-week-old SHR were randomized into atorvastatin treated group (ATV group, n=6) and distilled water group (DW group, n=6); Wistar-Kyoto rats (WKY) were used as normal controls. atorvastatin was administered to ATV group for 10 weeks by gavage in mixture with distilled water (1 ml); the latter two groups were given the same amount of distilled water by gavage for 10 weeks. Systolic blood pressure of caudal artery was examined before and after treatment, and serum concentrations of total cholesterol, triglycerides and HDL-C were measured. Wall thickness, media thickness, medial cross-sectional area and lumen diameter of thoracic aorta were assessed with computed video processing. Results: Systolic blood pressure in ATV group was markedly lower than that in DW group (P<0.01). Compared with DW group and WKY group, serum concentrations of total cholesterol, triglycerides and HDL-C in ATV group were significantly lower (P<0.01, P<0.05). Wall thickness, media thickness, and medial cross-sectional area to lumen ratio in DW group were significantly higher than those in WKY group and ATV group (P<0.01,P<0.05), but no such difference was found between WKY group and ATV group (P>0.05). Conclusion: Vascular structural changes of aorta are due to the alteration of the vessel wall in early stage of SHR. atorvastatin can markedly improve vascular remodeling.

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