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Received: 2003-09-30

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Bio-Design and Manufacturing  2022 Vol.5 No.4 P.494~498

10.1631/jzus.2004.0494


Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction


Author(s):  TAO Ze-wei, HUANG Yuan-wei, XIA Qiang, FU Jun, ZHAO Zhi-hong, LU Xian, BRUCE I.C.

Affiliation(s):  Department of Cardiology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   taozewei@zju.edu.cn

Key Words:  Electrocardiogram, Myocardial infarction, Cardiac function


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TAO Ze-wei, HUANG Yuan-wei, XIA Qiang, FU Jun, ZHAO Zhi-hong, LU Xian, BRUCE I.C.. Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction[J]. Journal of Zhejiang University Science D, 2022, 5(4): 494~498.

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pages="494~498",
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publisher="Zhejiang University Press & Springer",
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%T Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction
%A TAO Ze-wei
%A HUANG Yuan-wei
%A XIA Qiang
%A FU Jun
%A ZHAO Zhi-hong
%A LU Xian
%A BRUCE I.C.
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T1 - Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction
A1 - TAO Ze-wei
A1 - HUANG Yuan-wei
A1 - XIA Qiang
A1 - FU Jun
A1 - ZHAO Zhi-hong
A1 - LU Xian
A1 - BRUCE I.C.
J0 - Journal of Zhejiang University Science D
VL - 5
IS - 4
SP - 494
EP - 498
%@ 1869-1951
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2004.0494


Abstract: 
Objective: myocardial infarction (MI) is the main cause of heart failure, but the relationship between the extent of MI and cardiac function has not been clearly determined. The present study was undertaken to investigate early changes in the electrocardiogram associated with infarct size and cardiac function after MI.Methods: MI was induced by ligating the left anterior descending coronary artery in rats. electrocardiograms, echocardiographs and hemodynamic parameters were assessed and myocardial infarct size was measured from mid-transverse sections stained with Masson's trichrome. Results: The sum of pathological Q wave amplitudes was strongly correlated with myocardial infarct size (r = 0.920, P < 0.0001), left ventricular ejection fraction (r = -0.868, P < 0.0001) and left ventricular end diastolic pressure (r = 0.835, P < 0.0004). Furthermore, there was close relationship between MI size and cardiac function as assessed by left ventricular ejection fraction (r = -0.913, P < 0.0001) and left ventricular end diastolic pressure (r = 0.893, P < 0.0001). Conclusion: The sum of pathological Q wave amplitudes after MI can be used to estimate the extent of MI as well as cardiac function.

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