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Journal of Zhejiang University SCIENCE A 2005 Vol.6 No.7 P.640~642

http://doi.org/10.1631/jzus.2005.A0640


A new germacranolide from Carpesium cernuum


Author(s):  CAO Jian-xin, PAN Yuan-jiang, XU Chong-yang, HUANG Li-xia, MA Shu-hong, DAI Chang-liang, GAO Wan-wan

Affiliation(s):  Department of Chemistry, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   jxcao321@hotmail.com, panyuanjiang@zju.edu.cn

Key Words:  Carpesium cernuum, Compositae, Sesquiterpenoid, 2&alpha, , 3&beta, -dihydroxy-9-angeloxygermacra-4-en-6, 12-olide


CAO Jian-xin, PAN Yuan-jiang, XU Chong-yang, HUANG Li-xia, MA Shu-hong, DAI Chang-liang, GAO Wan-wan. A new germacranolide from Carpesium cernuum[J]. Journal of Zhejiang University Science A, 2005, 6(7): 640~642.

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author="CAO Jian-xin, PAN Yuan-jiang, XU Chong-yang, HUANG Li-xia, MA Shu-hong, DAI Chang-liang, GAO Wan-wan",
journal="Journal of Zhejiang University Science A",
volume="6",
number="7",
pages="640~642",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.A0640"
}

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%A CAO Jian-xin
%A PAN Yuan-jiang
%A XU Chong-yang
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%A MA Shu-hong
%A DAI Chang-liang
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.A0640

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T1 - A new germacranolide from Carpesium cernuum
A1 - CAO Jian-xin
A1 - PAN Yuan-jiang
A1 - XU Chong-yang
A1 - HUANG Li-xia
A1 - MA Shu-hong
A1 - DAI Chang-liang
A1 - GAO Wan-wan
J0 - Journal of Zhejiang University Science A
VL - 6
IS - 7
SP - 640
EP - 642
%@ 1673-565X
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.A0640


Abstract: 
As a part of our interest in biologically active germacranolides from the genus Carpesium (compositae), we have investigated the constituents of %29&ck%5B%5D=abstract&ck%5B%5D=keyword'>%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>Carpesium cernuum. This paper reports the isolation and structural elucidation of a new germacranolide, cernolide A (Compound 1), from the herb. The structure of Compound 1 was determined as 2&alpha;,3&beta;-dihydroxy-9-angeloxygermacra-4-en-6,12-olide on the basis of spectral evidence. The skeleton of Compound 1 was elucidation by IR, MS, 1H and 13C NMR, COSY, HMQC and HMBC experiments. The stereochemistry of Compound 1 was deduced by ROESY spectral data. Finally, the procedures of extraction and isolation were described in detail.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Dong, Y.F., Ding, Y.M., 1988. Sesquiterpene lactones from Carpesium abrotanoides. Zhiwu Xuebao, 30:71-75 (in Chinese).

[2] Kim, D.K., Baek, N.I., Choi, S.U., Lee, C.O., Lee, K.R., Lee, O.P., 1997. Four new cytotoxic germacranolides from Carpesium divaricatum. J. Nat. Prod., 60:1199-1202.

[3] Lin, Y.L., Ou, J.C., 1996. Napalolides A-D, four new sesquiterpene lactones from Carpesium nepalense. J. Nat. Prod., 59:991-993.

[4] Maruyama, M., 1990. Sesquiterpene lactones from Carpesium divaricatum. Phytochemistry, 29:547-550.

[5] Maruyama, M., Omura, S., 1977. Carpesiolin from Carpesium abrotanoides. Phytochemistry, 16:782-783.

[6] Masao, M., Akio, K., Kiyoko, S., 1983. Sesquiterpene lactones from Carpesium abrotanoides. Phytochemistry, 22:2273-2274.

[7] Yang, C., Wang, X., Shi, Y.P., Jia, Z.J., 2002. The study on the compounds of the aerial part of Carpesium cernuum. J. Lanzhou Univ. SCI, 38:61-66.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Ritesh@Phd student<riteshbiochem2006@gmail.com>

2010-12-03 15:28:52

Please provide me following article...

A new germacranolide from Carpesium cernuum

CAO Jian-xin, PAN Yuan-jiang, XU Chong-yang, HUANG Li-xia, MA Shu-hong, DAI Chang-liang, GAO Wan-wan

Department of Chemistry, Zhejiang University, Hangzhou 310027, China; Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China

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