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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.9 P.885~891

10.1631/jzus.2005.B0885


Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients


Author(s):  LU Xiao-yang, HUANG Hong-feng, SHENG-TU Jian-zhong, LIU Jian

Affiliation(s):  Department of Clinical Pharmacology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   lxy00711@yahoo.com.cn

Key Words:  Mycophenolate mofetil, Mycophenolic acid, Pharmacokinetics, Kidney transplant


LU Xiao-yang, HUANG Hong-feng, SHENG-TU Jian-zhong, LIU Jian. Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients[J]. Journal of Zhejiang University Science B, 2005, 6(9): 885~891.

@article{title="Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients",
author="LU Xiao-yang, HUANG Hong-feng, SHENG-TU Jian-zhong, LIU Jian",
journal="Journal of Zhejiang University Science B",
volume="6",
number="9",
pages="885~891",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0885"
}

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%T Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients
%A LU Xiao-yang
%A HUANG Hong-feng
%A SHENG-TU Jian-zhong
%A LIU Jian
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 9
%P 885~891
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0885

TY - JOUR
T1 - Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients
A1 - LU Xiao-yang
A1 - HUANG Hong-feng
A1 - SHENG-TU Jian-zhong
A1 - LIU Jian
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 9
SP - 885
EP - 891
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0885


Abstract: 
To assess the influence of cyclosporin A (CsA) and tacrolimus (FK506) on mycophenolic acid (MPA) and correlation analysis of the pharmacokinetic parameters and patient characteristics, clinical outcome in Chinese kidney transplant recipients, the pharmacokinetics of 1000 mg mycophenolate mofetil (MMF) twice daily was measured by high-performance liquid chromatography (HPLC). PKS (Pharmaceutical Kinetics Software) 1.0.2 software package was used for the calculation of pharmacokinetic parameters. The mean Cmax, tmax, and AUC(0−12)were (21.88±10.52) µg/ml, (1.20±0.95) h, and (52.546±13.215) µg·h/ml, respectively. The level of AUC(0−12) in the FK506 group was significantly higher than that in the CsA group. MPA appeared not to be affected by renal function. MPA AUC(0−12) showed statistically significant difference according to the patient’s gender.

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Reference

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