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Received: 2006-04-25

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.9 P.757-762


Effects of levobupivacaine and bupivacaine on rat myometrium

Author(s):  LI Zi-gang, ZHOU Liang, TANG Hui-fang

Affiliation(s):  Department of Anesthesiology, Women’ more

Corresponding email(s):   tanghuifang@zju.edu.cn

Key Words:  Levobupivacaine, Bupivacaine, Myometrium, Rat

LI Zi-gang, ZHOU Liang, TANG Hui-fang. Effects of levobupivacaine and bupivacaine on rat myometrium[J]. Journal of Zhejiang University Science B, 2006, 7(9): 757-762.

@article{title="Effects of levobupivacaine and bupivacaine on rat myometrium",
author="LI Zi-gang, ZHOU Liang, TANG Hui-fang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effects of levobupivacaine and bupivacaine on rat myometrium
%A LI Zi-gang
%A ZHOU Liang
%A TANG Hui-fang
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 9
%P 757-762
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0757

T1 - Effects of levobupivacaine and bupivacaine on rat myometrium
A1 - LI Zi-gang
A1 - ZHOU Liang
A1 - TANG Hui-fang
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 9
SP - 757
EP - 762
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0757

Objective: To study the effect of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine on the contractility of isolated uterine muscle strips from pregnant and non-pregnant female rats. Methods: Full-thick myometrial strips were prepared from 18- to 21-day pregnant (n=8) and non-pregnant rats (n=7). After contractions became regular, strips were exposed to cumulative concentrations of the two drugs from 10−8 to 10−4 mol/L, amplitude and frequency of the uterine contraction was recorded. Results: Two local anesthetics caused a concentration dependent inhibition on contractility of myometrial strips from pregnant and non-pregnant rats. In the myometrium from non-pregnant rats, −logIC50 of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine were 4.85 and 4.25 respectively. In the myometrium from pregnant rats, similar concentrations of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine were observed, −logIC50 were 2.7 and 2.9 respectively. bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine produced an increase in amplitude of contractions, while bupivacaine showed an increased trend in frequency. Conclusion: These results demonstrate that bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine and bupivacaine may inhibit myometrium contractility. The inhibitory effect of bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine or bupivacaine is not enhanced by gestation in rat. bupivacaine%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>levobupivacaine may have more positive influence than bupivacaine in pregnant myometrium.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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