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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.9 P.766~768

10.1631/jzus.2006.B0766


Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation?


Author(s):  LI Nan, WANG Jian-an

Affiliation(s):  Division of Clinical Pharmacology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   nli_zum@yahoo.com.cn, Wang_jian_an@tom.com

Key Words:  Mesenchymal stem cell transplantation, Brain natriuretic peptide, Cardiac function, Exercise capacity, Cardiomyogenesis


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LI Nan, WANG Jian-an. Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation?[J]. Journal of Zhejiang University Science B, 2006, 7(9): 766~768.

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author="LI Nan, WANG Jian-an",
journal="Journal of Zhejiang University Science B",
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pages="766~768",
year="2006",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2006.B0766"
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%T Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation?
%A LI Nan
%A WANG Jian-an
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 9
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0766

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T1 - Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation?
A1 - LI Nan
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2006.B0766


Abstract: 
We observed in a pilot study that there was a transient elevation of brain natriuretic peptide (BNP) level shortly after the transplantation in the patient with ischemic heart failure, which is unexplainable by the simultaneous increase of the cardiac output and six-minute walk distance. Similar findings were observed in the phase I trial. We postulated on the basis of the finding of Fukuda in vitro that this transient elevation of BNP level against the improvement of cardiac function and exercise capacity might indicate cardiomyogenesis in patients after mesenchymal stem cell transplantation. Further study is warranted to verify the hypothesis.

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Reference

[1] Dai, W.D., Hale, S.L., Martin, B.J., Kuang, J.Q., Dow, J.S., Wold, L.E., Kloner, R.A., 2005. Allogenic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation, 112(2):214-223.

[2] Dick, A.J., Guttman, M.A., Raman, V.K., Peters, D.C., Pessanha, B.S., Hill, J.M., Smith, S., Scott, G., McVeigh, E.R., Lederman, R.J., 2003. Magnetic resonance fluoroscopy allows targeted delivery of mesenchymal stem cells to infarct borders in Swine. Circulation, 108(23):2899-2904.

[3] Fukuda, K., 2002. Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytes. C. R. Biol., 325(10):1027-1038.

[4] Li, N., Wang, J.A., 2005. Brain natriuretic peptide and optimal management of heart failure. J. Zhejiang Univ. SCIENCE, 6B(9):877-884.

[5] Pittenger, M.F., Martin, B.J., 2004. Mesenchymal stem cells and their potential as cardiac therapeutics. Circulation Research, 95(1):9.

[6] Shake, J.G., Gruber, P.J., Baumgartner, W.A., Senechal, G., Meyers, J., Redmond, J.M., Pittenger, M.F., Martin, B.J., 2002. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann. Thorac. Surg., 73(6):1919-1926.

[7] Tang, Y.L., Zhao, Q., Zhang, Y.C., Cheng, L., Liu, M., Shi, J., Yang, Y.Z., Pan, C., Ge, J., Phillips, M.I., 2004. Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul. Pept., 117(1):3-10.

[8] Wang, J.A., Li, C.L., Fan, Y.Q., He, H., Sun, Y., 2004. Allograft bone marrow-derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart. J. Zhejiang Univ. SCIENCE, 5(10):1279-1285.

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