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Journal of Zhejiang University SCIENCE A 2007 Vol.8 No.9 P.1521~1526

10.1631/jzus.2007.A1521


Lovastatin production by Aspergillus terreus in solid-state fermentation


Author(s):  WEI Pei-lian, XU Zhi-nan, CEN Pei-lin

Affiliation(s):  Institute of Biochemical Engineering, Department of Chemical Engineering & Bioengineering, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   weipeilian@126.com, cenpl@zju.edu.cn

Key Words:  Solid-state fermentation (SSF), Rice, Lovastatin, Aspergillus terreus


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WEI Pei-lian, XU Zhi-nan, CEN Pei-lin. Lovastatin production by Aspergillus terreus in solid-state fermentation[J]. Journal of Zhejiang University Science A, 2007, 8(9): 1521~1526.

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%T Lovastatin production by Aspergillus terreus in solid-state fermentation
%A WEI Pei-lian
%A XU Zhi-nan
%A CEN Pei-lin
%J Journal of Zhejiang University SCIENCE A
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.A1521

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T1 - Lovastatin production by Aspergillus terreus in solid-state fermentation
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A1 - CEN Pei-lin
J0 - Journal of Zhejiang University Science A
VL - 8
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SP - 1521
EP - 1526
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2007.A1521


Abstract: 
lovastatin production by Aspergillus terreus ATCC 20542 in solid-state fermentation (SSF) was studied. Various substrates were used to evaluate the ability of A. terreus to produce lovastatin. The results showed that either rice or wheat bran was suitable substrate for lovastatin production in SSF. The maximum yield of lovastatin (2.9 mg/g dry substrate) using rice as substrate was achieved after incubating for 11 d at the following optimized process parameters: 50%~60% initial moisture content, pH 5.5, incubation temperature 28 °C.

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