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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.5 P.307~313

10.1631/jzus.2007.B0307


Comparison of pharmacokinetics, efficacy and toxicity profile of gemcitabine using two different administration regimens in Chinese patients with non-small-cell lung cancer


Author(s):  WANG Lin-run, LIU Jian, HUANG Ming-zhu, XU Nong

Affiliation(s):  Department of Clinical Pharmacy, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   linrunw@yahoo.com.cn, hmzj2002@yahoo.com.cn

Key Words:  Gemcitabine, Non-small-cell lung cancer, Pharmacokinetics, Qualified response, Safety


WANG Lin-run, LIU Jian, HUANG Ming-zhu, XU Nong. Comparison of pharmacokinetics, efficacy and toxicity profile of gemcitabine using two different administration regimens in Chinese patients with non-small-cell lung cancer[J]. Journal of Zhejiang University Science B, 2007, 8(5): 307~313.

@article{title="Comparison of pharmacokinetics, efficacy and toxicity profile of gemcitabine using two different administration regimens in Chinese patients with non-small-cell lung cancer",
author="WANG Lin-run, LIU Jian, HUANG Ming-zhu, XU Nong",
journal="Journal of Zhejiang University Science B",
volume="8",
number="5",
pages="307~313",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0307"
}

%0 Journal Article
%T Comparison of pharmacokinetics, efficacy and toxicity profile of gemcitabine using two different administration regimens in Chinese patients with non-small-cell lung cancer
%A WANG Lin-run
%A LIU Jian
%A HUANG Ming-zhu
%A XU Nong
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 5
%P 307~313
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0307

TY - JOUR
T1 - Comparison of pharmacokinetics, efficacy and toxicity profile of gemcitabine using two different administration regimens in Chinese patients with non-small-cell lung cancer
A1 - WANG Lin-run
A1 - LIU Jian
A1 - HUANG Ming-zhu
A1 - XU Nong
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 5
SP - 307
EP - 313
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0307


Abstract: 
Objective: To conduct a randomized comparative trial of pharmacokinetics, efficacy and toxicity profile treatment with 1 200 mg/m2 gemcitabine using standard 30-min infusion or fixed dose rate (FDR) infusion [10 mg/(m2·min)] on days 1 and 8 plus carboplatin AUC (area under curve) 5 on day 1 in Chinese non-small-cell cancer patients. Twelve patients were enrolled in this study. Methods: Plasma gemcitabine concentrations were measured by ion-pair reversed phase high performance liquid chromatography. Antitumoral activity and toxicity of gemcitabine was assessed according to World Health Organization criteria. Results: The obtained mean parameters, such as T1/2 (elimination half time), AUC, and CL (clearance), were consistent with those reported in literature. qualified response rate in our study was 33.3% for standard arm and 50% for FDR arm. Additional 50% and 33.3% patients contracted stable disease (SD) in standard arm and FDR arm, respectively. The predominant toxicity was hematologic, and patients in the standard infusion arm experienced consistently more hematologic toxicity. Conclusion: Pharmacokinetic and clinical data in this trial support the continued evaluation of the FDR infusion strategy with gemcitabine.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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