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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.5 P.323~330

10.1631/jzus.2007.B0323


Effects of chromium nanoparticle dosage on growth, body composition, serum hormones and tissue chromium in Sprague-Dawley rats


Author(s):  ZHA Long-ying, XU Zi-rong, WANG Min-qi, GU Liang-ying

Affiliation(s):  Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Science Institute, Zhejiang University, Hangzhou 310029, China

Corresponding email(s):   zrxuzju@126.com

Key Words:  Rat, Chromium (Cr), Nanoparticle, Growth, Body composition, Hormone


ZHA Long-ying, XU Zi-rong, WANG Min-qi, GU Liang-ying. Effects of chromium nanoparticle dosage on growth, body composition, serum hormones and tissue chromium in Sprague-Dawley rats[J]. Journal of Zhejiang University Science B, 2007, 8(5): 323~330.

@article{title="Effects of chromium nanoparticle dosage on growth, body composition, serum hormones and tissue chromium in Sprague-Dawley rats",
author="ZHA Long-ying, XU Zi-rong, WANG Min-qi, GU Liang-ying",
journal="Journal of Zhejiang University Science B",
volume="8",
number="5",
pages="323~330",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0323"
}

%0 Journal Article
%T Effects of chromium nanoparticle dosage on growth, body composition, serum hormones and tissue chromium in Sprague-Dawley rats
%A ZHA Long-ying
%A XU Zi-rong
%A WANG Min-qi
%A GU Liang-ying
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 5
%P 323~330
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0323

TY - JOUR
T1 - Effects of chromium nanoparticle dosage on growth, body composition, serum hormones and tissue chromium in Sprague-Dawley rats
A1 - ZHA Long-ying
A1 - XU Zi-rong
A1 - WANG Min-qi
A1 - GU Liang-ying
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 5
SP - 323
EP - 330
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0323


Abstract: 
This 6-week study was conducted to evaluate the effects of seven different levels of dietary chromium (Cr) (0, 75, 150, 300, 450, 600, and 1 200 ppb Cr) in the form of Cr nanoparticle (CrNano) on growth, body composition, serum hormones and tissue Cr in Sprague-Dawley (SD) rats. Seventy male SD rats (average initial body weight of (83.2±4.4) g) were randomly assigned to seven dietary treatments (n=10). At the end of the trial, body composition was assessed via dual energy X-ray absorptiometry (DEXA). All rats were then sacrificed to collect samples of blood, organs and tissues for determination of serum hormones and tissue Cr contents. The results indicated that lean body mass was significantly increased (P<0.05) due to the addition of 300 and 450 ppb Cr from CrNano. Supplementation of 150, 300, 450, and 600 ppb Cr decreased (P<0.05) percent body fat significantly. Average daily gain was increased (P<0.05) by addition of 75, 150, and 300 ppb Cr and feed efficiency was increased (P<0.05) by supplementation of 75, 300, and 450 ppb Cr. Addition of 300 and 450 ppb Cr decreased (P<0.05) the insulin level in serum greatly. Cr contents in liver and kidney were greatly increased (P<0.05) by the addition of Cr as CrNano in the dosage of from 150 ppb to 1 200 ppb. In addition, Supplementation of 300, 450, and 600 ppb Cr significantly increased (P<0.05) Cr content in the hind leg muscle. These results suggest that supplemental CrNano has beneficial effects on growth performance and body composition, and increases tissue Cr concentration in selected muscles.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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