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Received: 2007-04-03

Revision Accepted: 2007-09-19

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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.12 P.875~880


Relationship between resistin level in serum and acute coronary syndrome or stable angina pectoris

Author(s):  Qiao Xiao-zhi, Yang Yun-mei, Xu Zhe-rong, Yang Li-ai

Affiliation(s):  Department of Very Important Person, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   qxz1971@hzcnc.com, gbbf2000@sina.com

Key Words:  Resistin, Acute coronary syndrome (ACS), Stable angina pectoris (SAP)

Qiao Xiao-zhi, Yang Yun-mei, Xu Zhe-rong, Yang Li-ai. Relationship between resistin level in serum and acute coronary syndrome or stable angina pectoris[J]. Journal of Zhejiang University Science B, 2007, 8(12): 875~880.

@article{title="Relationship between resistin level in serum and acute coronary syndrome or stable angina pectoris",
author="Qiao Xiao-zhi, Yang Yun-mei, Xu Zhe-rong, Yang Li-ai",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Relationship between resistin level in serum and acute coronary syndrome or stable angina pectoris
%A Qiao Xiao-zhi
%A Yang Yun-mei
%A Xu Zhe-rong
%A Yang Li-ai
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 12
%P 875~880
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0875

T1 - Relationship between resistin level in serum and acute coronary syndrome or stable angina pectoris
A1 - Qiao Xiao-zhi
A1 - Yang Yun-mei
A1 - Xu Zhe-rong
A1 - Yang Li-ai
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 12
SP - 875
EP - 880
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0875

Objective: To investigate the relationship between serum resistin level and acute coronary syndrome (ACS) or stable angina pectoris (SAP). Methods: Sixty-five patients, with coronary artery disease, were enrolled and divided into three subgroups: acute myocardial infarction (AMI), unstable angina pectoris (UAP) and SAP, and 26 healthy people were recruited as controls in the cross-sectional study. Serum resistin levels were determined by ELISA (enzyme-linked immunosorbent assay), and WBC (white blood cell count), hsCRP (high sensitive C-reaction protein), CKmax (maximum of creatinkinase), CK-MBmax (maximum of isozyme of creatinkinase) and cTnImax (maximum of troponin) were measured by standard laboratory methods. Results: The serum resistin levels were 4 folds higher in AMI patients, 2.43 folds in UAP patients and 1.12 folds in SAP patients than in the healthy controls (P<0.05). The resistin levels were also significantly different between AMI [(8.16±0.79) ng/ml], UAP [(5.59±0.75) ng/ml] and SAP [(3.45±0.56) ng/ml] groups (P<0.01); WBC, hsCRP, CKmax, CK-MBmax and cTnImax were significantly increased in AMI patients over UAP and SAP patients. Spearman analysis showed that serum resistin levels were positively correlated with WBC (r=0.412, P=0.046), hsCRP (r=0.427, P=0.037), CKmax, CK-MBmax and cTnImax (r=0.731, 0.678, 0.656; P<0.01). Conclusion: Serum resistin levels increased with inflammatory factors and myocardial impairment. The results suggest that human resistin might play an important role in the pathogenesis of atherosclerosis and AMI as an inflammatory factor.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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