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CLC number: R737.9

On-line Access: 2008-01-06

Received: 2007-12-08

Revision Accepted: 2007-12-13

Crosschecked: 0000-00-00

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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.2 P.85~89

10.1631/jzus.B0710617


BRCA1/2 associated hereditary breast cancer


Author(s):  Li-song TENG, Yi ZHENG, Hao-hao WANG

Affiliation(s):  Cancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   lsteng@zju.edu.cn

Key Words:  BRCA1, BRCA2, Hereditary breast cancer


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Li-song TENG, Yi ZHENG, Hao-hao WANG. BRCA1/2 associated hereditary breast cancer[J]. Journal of Zhejiang University Science B, 2008, 9(2): 85~89.

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Abstract: 
Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial; further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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