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CLC number: R394

On-line Access: 2008-01-06

Received: 2007-12-04

Revision Accepted: 2007-12-27

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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.2 P.90-92


Mitochondrion and its related disorders: Making a comeback

Author(s):  Xian-ning ZHANG, Ming QI

Affiliation(s):  Zhejiang University-Adinovo Center for Genetic and Genomic Medicine, Zhejiang University, Hangzhou 310058, China; more

Corresponding email(s):   zhangxianning@zju.edu.cn, qiming_14618@yahoo.com

Key Words:  Mitochondria, Mitochondrial disorder, Mutation

Xian-ning ZHANG, Ming QI. Mitochondrion and its related disorders: Making a comeback[J]. Journal of Zhejiang University Science B, 2008, 9(2): 90-92.

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The great majority of genetic disorders are caused by defects in the nuclear genome. However, some significant diseases are the result of mitochondrial mutations. Because of the unique features of the mitochondria, these diseases display characteristic modes of inheritance and a large degree of phenotypic variability. Recent studies have suggested that mitochondrial dysfunction plays a central role in a wide range of age-related disorders and various forms of cancer.

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