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Received: 2007-12-23

Revision Accepted: 2008-03-02

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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.6 P.500-505


Adrenal myelolipoma within myxoid cortical adenoma associated with Conn’s syndrome

Author(s):  Hong-sheng LU, Mei-fu GAN, Han-song CHEN, Shan-qiang HUANG

Affiliation(s):  Department of Pathology, Taizhou Hospital, Linhai 317000, China

Corresponding email(s):   luhongsheng00@163.com

Key Words:  Adrenal gland, Myxoid adrenal cortical adenoma, Myelolipoma, Conn&rsquo, s syndrome, Pathology, Immunohistochemistry

Hong-sheng LU, Mei-fu GAN, Han-song CHEN, Shan-qiang HUANG. Adrenal myelolipoma within myxoid cortical adenoma associated with Conn’s syndrome[J]. Journal of Zhejiang University Science B, 2008, 9(6): 500-505.

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publisher="Zhejiang University Press & Springer",

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%T Adrenal myelolipoma within myxoid cortical adenoma associated with Conn’s syndrome
%A Hong-sheng LU
%A Mei-fu GAN
%A Han-song CHEN
%A Shan-qiang HUANG
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
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T1 - Adrenal myelolipoma within myxoid cortical adenoma associated with Conn’s syndrome
A1 - Hong-sheng LU
A1 - Mei-fu GAN
A1 - Han-song CHEN
A1 - Shan-qiang HUANG
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 6
SP - 500
EP - 505
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Y1 - 2008
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B0720014

The coexistence of myelolipoma within adrenal cortical adenoma is extremely rare, for both tumors present usually as separate entities. There are only 16 such cases reported worldwide. To the best of our knowledge, the case we reported here is the first one of myxoid adrenal cortical adenoma associated with myelolipoma reported. A 32-year-old Chinese woman with 4-year history of hypertension was presented in our study. Computed tomography (CT) of the abdomen showed a large heterogeneously-enhancing mass (4.5 cm in diameter) in the left suprarenal region. Clinical history and laboratory results suggest a metabolic disorder as conn&rsquo;s syndrome. The patient underwent a left adrenalectomy, and a histopathological study confirmed the mass to be a myxoid adrenal cortical adenoma containing myelolipoma. The patient was postoperatively well and discharged uneventfully. In the present case report, we also discuss the etiology of simultaneous myelolipoma and adrenal adenoma associated with conn&rsquo;s syndrome, and the methods of the diagnosis and differential diagnosis.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1] Ammoury, R.F., heptulla, R.A., Tatevian, N., Elenberg, E., 2006. Laparscopic adrenalectomy of an adrenal adenoma with myelolipoma relieves severe hypertension in a 16-year-old patient. Pediatr. Nephrol., 21(3):433-436.

[2] Armand, R., Cappola, A.R., Horenstein, R.B., 2004. Adrenal cortical adenoma with excess black pigment deposition, combined with myelolipoma and clinical Cushing’s syndrome. Int. J. Surg. Pathol., 12(1):57-61.

[3] Cho, T., kitazono, S., Tanimura, A., Itoh, Y., 1984. Cortical adenoma of the adrenal gland assiciated with multiple tumors. Byorito. Risho., 21(2):101-107 (in Japanese).

[4] Cormio, L., Ruutu, M., Giardina, C., Selvaggi, F.P., 1992. Combined adrenal adenoma and myelolipoma in a patient with Conn’s syndrome. Case Report. Panminerva Med., 34(4):209-212.

[5] Forsthoefel, K.F., 1994. Myxoid adrenal cortical carcinoma: a case report with differential diagnostic considerations. Arch. Pathol. Lab. Med., 118(11):1151-1153.

[6] Fujita, Y., Amemiya, H., Shibuya, A., 1985. Adrenal calcification and myelolipoma associated with Cushing’s syndrome. Jikerkai Med. J., 32(9):495-501.

[7] Han, M., Burnett, A.L., Fishman, E.K., Marshall, F.F., 1997. The natural history and treatment of adrenal myelolipoma. J. Urol., 157(4):1213-1216.

[8] Hisamatsu, H., Sakai, H., Tsuda, S., Shigematsu, K., Kanetake, H., 2004. Combined adrenal adenoma and myelolipoma in a patient with Cushing’s syndrome: case report and review of the literature. Int. J. Urol., 11(6):416-418.

[9] Honda, K., Kashima, K., Daa, T., Gamachi, A., Nakayama, L., Yokoyama, S., 2001. Myxoid adrenal cortical adenoma. Pathology International, 51(11):887-891.

[10] Ide, H., Terado, Y., Nakagawa, T., Saito, K., Kamiyama, Y., Muto, S., Okada, H., Imamura, T., Horic, S., 2007. Incidentally discovered adrenal myelolipoma associated with hyperthyroidism. Int. J. Clin. Oncol., 12(5):379-381.

[11] Jiang, H.F., Huang, X.H., 2002. Myelolipomatous nodules within a myxoid adrenal cortical adenoma. J. Clin. Exp. Pathol., 18(4):449-450 (in Chinese).

[12] Manassero, F., Pomara, G., Rappa, F., Cuttano, M.G., Crisci, A., Selli, C., 2004. Adrenal myelolipoma associated with adenoma. Int. J. Urol., 11(5):326-328.

[13] Matsuda, T., Abe, H., Takase, M., Arakawa, A., Matsumoto, T., Fujime, M., Suda, K., 2004. Case of combined adrenal cortical adenoma and myelolipoma. Pathology International, 54(9):725-729.

[14] Miyake, O., Hara, T., Matsumiya, K., Oka, T., Takaha, M., Kurata, A., 1992. Adrenal myelolipoma associated with Cushing’s syndrome: a case report. Hinyokika Kiyo, 38(6):681-684 (in Japanese).

[15] Murayama, H., Kikuchi, M., Imai, T., 1979. Myelolipoma in adenoma of accessory adrenal gland. Pathol. Res. Pract., 164(2):207-213.

[16] Olsson, C.A., Krane, R.J., Klugo, R.C., Selikowitz, S.M., 1973. Adrenal myelolopoma. Surgery, 73(8):665-670.

[17] Ong, K., Tan, K.B., Putti, T.C., 2007. Myelolipoma within a non-functional adrenal cortical adenoma. Singapore Med. J., 48(7):200-202.

[18] Saito, Y., Hayasaka, K., Kikuchi, Y., Amous, K., Miyata, M., 1988. A case of comined adrenal myelolipoma and adenoma. Rinshogazo, 4(1):88-92 (in Japanese).

[19] Vrezas, I., Wentworth, P., Bornstein, S.R., 2003. Myelolipomatous foci in an adrenal adenoma causing Cushing’s syndrome? Endocr. Res., 29(1):67-71.

[20] Vyberg, M., Sestoft, L., 1986. Combined adrenal myelolipoma and adenoma associated with Cushing’s syndrome. Am. J. Clin. Pathol., 86(4):541-545.

[21] Yamada, T., Ishibashi, T., Saito, H., Majima, K., Tsuda, M., Takahashi, S., Moriya, T., 2002. Non-functioning adrenocortical adenomas containing fat components. Clin. Radiol., 57(11):1034-1037.

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