Full Text:
<4379>
CLC number: R737
On-line Access:
Received: 2007-11-07
Revision Accepted: 2008-01-07
Crosschecked: 0000-00-00
Cited: 7
Clicked: 7639
Primary leiomyosarcoma of the nipple-areola complex: Report of a case and review of literature
| |||||||||||||
Lai-ching WONG, Po-chi HUANG, Shi-ping LUH, Chiun-sheng HUANG. Primary leiomyosarcoma of the nipple-areola complex: Report of a case and review of literature[J]. Journal of Zhejiang University Science B, 2008, 9(2): 109-113.
@article{title="Primary leiomyosarcoma of the nipple-areola complex: Report of a case and review of literature",
author="Lai-ching WONG, Po-chi HUANG, Shi-ping LUH, Chiun-sheng HUANG",
journal="Journal of Zhejiang University Science B",
volume="9",
number="2",
pages="109-113",
year="2008",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0720246"
}
%0 Journal Article
%T Primary leiomyosarcoma of the nipple-areola complex: Report of a case and review of literature
%A Lai-ching WONG
%A Po-chi HUANG
%A Shi-ping LUH
%A Chiun-sheng HUANG
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 2
%P 109-113
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0720246
TY - JOUR
T1 - Primary leiomyosarcoma of the nipple-areola complex: Report of a case and review of literature
A1 - Lai-ching WONG
A1 - Po-chi HUANG
A1 - Shi-ping LUH
A1 - Chiun-sheng HUANG
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 2
SP - 109
EP - 113
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0720246
Abstract: Primary leiomyosarcoma of the nipple-areola complex is extremely rare. Less than ten such cases have been reported in English literature so far. Herein we describe a 52-year-old female presenting with a 1.5 cm×1.1 cm×0.7 cm nodular lesion over her left nipple, and leiomyosarcoma was proved by pathological examination of the excised specimen. Positron emitted tomogram (PET) revealed no abnormal signal other than the primary site. Microscopically, this poorly circumscribed tumor was composed of interlacing bundles of smooth muscle cells with bizarre and pleomorphic nuclei, as well as prominent nucleoli. Its mitotic count was up to 7 mitoses per 10 high power fields (HPF). Immunohistochemical study of tumor cells revealed positive stain for α-smooth muscle actin and vimentin; and negative for cytokeratin, CD34 and S-100. Left simple mastectomy was undertaken and no residual mass lesion was noted on the resected specimen. Related literatures about the diagnosis and treatment for breast leiomyosarcoma will be presented here.
[1] Abd El All, H.S., 2006. Breast spindle cell tumours: About eight cases. Diagn. Pathol., 1(1):13.
[2] Adem, C., Reynolds, C., Ingle, J.N., Nascimento, A.G., 2004. Primary breast sarcoma: Clinicopathologic series from the Mayo clinic and review of the literature. Br. J. Cancer, 91:237-241.
[3] Choy, C., Cooper, A., Kossard, S., 2006. Primary cutaneous diffuse leiomyosarcoma with desmoplasia. Aust. J. Dermatol., 47(4):291-295.
[4] Cohen, D.T., Oliva, E., Hahn, P.F., Fuller, A.F.Jr, Lee, S.I., 2007. Uterine smooth-muscle tumors with unusual growth patterns: Imaging with pathologic correlation. AJR Am. J. Roentgenol., 188(1):246-255.
[5] Gupta, R.K., 2007. Needle aspiration cytology and immunohistologic findings in a case of leiomyosarcoma of the breast. Diagn. Cytopathol., 35(4):254-256.
[6] Holst, V.A., Junkins-Hopkins, J.M., Elenitsas, R., 2002. Cutaneous smooth muscleneoplasms: Clinical features, histologic findings, and treatment options. J. Am. Acad. Dermatol., 46(4):477-490.
[7] Hussien, M., Sivananthan, S., Anderson, N., Shiels, A., Tracey, N., Odling-Smee, G.W., 2001. Primary leiomyosarcoma of the breast: Diagnosis, management and outcome. A report of a new case and review of literature. Breast, 10(6):530-534.
[8] Insabato, L., Di Vizio, D., Ciancia, G., Pettinato, G., Tornillo, L., Terracciano, L., 2004. Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells. Arch. Pathol. Lab. Med., 128:440-443.
[9] Jayaram, G., Jayalakshmi, P., Yip, C.H., 2005. Leiomyosarcoma of the breast: Report of a case with fine needle aspiration cytologic, histologic and immunohistochemical features. Acta Cytol., 49:656-660.
[10] Lin, C.H., Yeh, C.N., Chen, M.F., 2003. Breast metastasis from uterine leiomyosarcoma: A case report. Arch. Gynecol. Obstet., 267:233-235.
[11] Lonsdale, R.N., Widdison, A., 1992. Leiomyosarcoma of the nipple. Histopathology, 20(6):537-539.
[12] Markaki, S., Sotiropoulou, M., Hanioti, C., Lazaris, D., 2003. Leiomyosarcoma of the breast. A clinicopathologic and immunohistochemical study. European Journal of Obstetrics and Gynecology and Reproductive Biology, 106(2):233-236.
[13] Munitiz, V., Rios, A., Canovas, J., Ferri, B., Sola, J., Canovas, P., Illana, J., Parrilla, P., 2004. Primitive leiomyosarcoma of the breast: Case report and review of the literature. Breast, 13(1):72-76.
[14] Ragsdale, B.D., 1997. Lever’s Histopathology of the Skin, 8th Ed. Lippincott-Raven, Chapter 35, p.959-960.
[15] Szekely, E., Madaras, L., Kulka, J., Jaray, B., Nagy, L., 2001. Leiomyosarcoma of the female breast. Pathol. Oncol. Res., 7:151-153.
[16] Taillibert, S., Spano, J.P., Genestie, C., Khayat, D., 2000. A mesocolic leiomyosarcoma metastatic to the breast: Case report and review of the literature. Anticancer Res., 20:4867-4869.
[17] Tavassoli, F.A., Devilee, P., 2003. World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of the Breast and Female Genital Organs. IARCPress, Lyon, p.98.
[18] Uğraş, S., Dilek, O.N., Karaayvaz, M., Dilek, H., Peker, Ö., Barut, I., 1997. Primary leiomyosarcoma of the breast. Jpn. J. Surg., 27:1082-1085.
[19] Vu, L.T., Luce, J., Knudson, M.M., 2006. Image of the month-leiomyosarcoma of the breast. Arch. Surg., 141(12):1263-1264.
Open peer comments: Debate/Discuss/Question/Opinion
<1>