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Received: 2007-12-03

Revision Accepted: 2007-12-10

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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.1 P.5~9

http://doi.org/10.1631/jzus.B073003


HER2 over-expression and response to different chemotherapy regimens in breast cancer


Author(s):  Jin ZHANG, Yan LIU

Affiliation(s):  Department of Breast Cancer, Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China

Corresponding email(s):   davidz9132002@yahoo.com

Key Words:  Breast cancer, HER2, Chemotherapy


Jin ZHANG, Yan LIU. HER2 over-expression and response to different chemotherapy regimens in breast cancer[J]. Journal of Zhejiang University Science B, 2008, 9(1): 5~9.

@article{title="HER2 over-expression and response to different chemotherapy regimens in breast cancer",
author="Jin ZHANG, Yan LIU",
journal="Journal of Zhejiang University Science B",
volume="9",
number="1",
pages="5~9",
year="2008",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B073003"
}

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%T HER2 over-expression and response to different chemotherapy regimens in breast cancer
%A Jin ZHANG
%A Yan LIU
%J Journal of Zhejiang University SCIENCE B
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%P 5~9
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%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B073003

TY - JOUR
T1 - HER2 over-expression and response to different chemotherapy regimens in breast cancer
A1 - Jin ZHANG
A1 - Yan LIU
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 1
SP - 5
EP - 9
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B073003


Abstract: 
Purpose: To exam the relationship between HER2 over-expression and different adjuvant chemotherapies in breast cancer. Patients and Methods: A total of 1625 primary breast cancer patients who received post-surgery adjuvant chemotherapy in Tianjin Cancer Hospital, China, from July 2002 to November 2005 were included in the study. Among them, 600 patients were given CMF (CTX+MTX+5-Fu) regimen, 600 given CEF (CTX+E-ADM+5-Fu) regimen, and 425 given anthracyclines plus taxanes regimen, with mean follow-up time of 42 months. Results: In CMF treatment group, the 3-year disease free survival (DFS) in HER2 over-expressed patients was lower than that of the HER2-negative ones (89.80% vs 91.24%, P=0.0348); in node-positive subgroup, the 3-year DFS was 84.72% in HER2 over-expressed patients, and 90.18% in the HER-2-negative ones (P=0.0271). Compared to CMF regimen, anthracyclines and anthracyclines plus taxanes regimens are more effective (P<0.05) in node-positive HER2 over-expression than those in the node-negative. Conclusion: HER2 over-expression is an independent index for predicting poor prognosis and short DFS for breast cancer patients. HER2 over-expressed patients are resistant to CMF regimen chemotherapy, but sensitive to anthracyclines-based or anthracyclines plus taxanes regimen. HER2 expression can be taken as a marker for therapies in breast cancer.

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Reference

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