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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.8 P.649-655


Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF

Author(s):  Yu-li QIAN, Ying-hui YE, Chen-ming XU, Fan JIN, He-feng HUANG

Affiliation(s):  Department of Reproductive Endocrinology, Women’ more

Corresponding email(s):   yeyh1999@hotmail.com

Key Words:  Embryo score, Combined scoring system (CSS), Implantation, In vitro fertilization (IVF), Pregnancy

Yu-li QIAN, Ying-hui YE, Chen-ming XU, Fan JIN, He-feng HUANG. Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF[J]. Journal of Zhejiang University Science B, 2008, 9(8): 649-655.

@article{title="Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF",
author="Yu-li QIAN, Ying-hui YE, Chen-ming XU, Fan JIN, He-feng HUANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF
%A Yu-li QIAN
%A Ying-hui YE
%A Chen-ming XU
%A Fan JIN
%A He-feng HUANG
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 8
%P 649-655
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820003

T1 - Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF
A1 - Yu-li QIAN
A1 - Ying-hui YE
A1 - Chen-ming XU
A1 - Fan JIN
A1 - He-feng HUANG
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 8
SP - 649
EP - 655
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820003

Objective: To evaluate the accuracy of a scoring system combining zygote and embryo morphology in predicting the outcome of in vitro fertilization (IVF) treatment. Methods: In a study group, 117 consecutive IVF or intracytoplasmic sperm injection (ICSI) cycles with embryo transfer were carried out and 312 embryos were scored using a combined scoring system (CSS) of zygote and embryo morphology before transplantation. In a control group, a total of 420 IVF or ICSI cycles were carried out and 1176 embryos were scored using a cumulative embryo score (CES). The effects of the combined scoring system on the embryo implantation rate and pregnancy rate per cycle were analyzed. Results: Using the combined scoring system, the embryo implantation rate (27.6%) and the clinical pregnancy rate (48.7%) were significantly higher than those in the control group (20.8% and 38.6%, respectively). Also, the implantation rate of embryos scoring ≥70 (38.5%: 82 sacs/213 embryos) was significantly higher (P<0.001) than that of embryos scoring <70 (4%: 4 sacs/99 embryos). The pregnancy rate of patients with embryos scoring ≥70 using the combined scoring system (66.7%) was significantly higher (P<0.001) than that of patients with embryos scoring ≥20 using the cumulative embryo score (59.0%). Conclusion: The results suggest that selecting embryos with a high score (≥70) using the combined scoring system could increase the implantation rate and pregnancy rate, and that using a scoring system combining assessments of human zygotes and pre-implantation embryos might predict IVF outcomes more accurately than using a cumulative embryo score.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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