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Received: 2008-03-20

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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.9 P.701~706

10.1631/jzus.B0820090


Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells


Author(s):  Yu-bin JI, Shi-yong GAO

Affiliation(s):  Postdoctoral Research Station of the Institute of Materia Medica, Center for Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China; more

Corresponding email(s):   sygao2002@163.com

Key Words:  Arylamine N-acetyltransferases (NATs), Apoptosis, HepG2, Camptothecin (CAM)


Yu-bin JI, Shi-yong GAO. Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells[J]. Journal of Zhejiang University Science B, 2008, 9(9): 701~706.

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author="Yu-bin JI, Shi-yong GAO",
journal="Journal of Zhejiang University Science B",
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pages="701~706",
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doi="10.1631/jzus.B0820090"
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%T Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells
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%A Shi-yong GAO
%J Journal of Zhejiang University SCIENCE B
%V 9
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%P 701~706
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%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820090

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T1 - Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells
A1 - Yu-bin JI
A1 - Shi-yong GAO
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SP - 701
EP - 706
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B0820090


Abstract: 
Objective: To explore how arylamine N-acetyltransferases (NATs) is related to cell apoptosis. Methods: NAT activity in apoptotic hepG2 cells was measured using high performance liquid chromatography (HPLC); the apoptosis rate of hepG2 cells acted upon by an NAT inhibitor was measured using flow cytometry. Results: NAT activity was lowered in apoptotic hepG2 cells; apoptosis rate induced by camptothecin (CAM) increased after inhibition of NAT activity in hepG2 cells. Conclusion: NAT can inhibit apoptosis in hepG2 cells.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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