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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.7 P.493~498

10.1631/jzus.B0820265


Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis


Author(s):  Xi-ping ZHANG, Han-qing CHEN, Fang LIU, Jie ZHANG

Affiliation(s):  Department of General Surgery, Hangzhou First People’ more

Corresponding email(s):   zxp99688@vip.163.com

Key Words:  Severe acute pancreatitis (SAP), Immune, Dysregulation, Treatment


Xi-ping ZHANG, Han-qing CHEN, Fang LIU, Jie ZHANG. Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis[J]. Journal of Zhejiang University Science B, 2009, 10(7): 493~498.

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author="Xi-ping ZHANG, Han-qing CHEN, Fang LIU, Jie ZHANG",
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volume="10",
number="7",
pages="493~498",
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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820265"
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%T Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis
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%A Han-qing CHEN
%A Fang LIU
%A Jie ZHANG
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 7
%P 493~498
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820265

TY - JOUR
T1 - Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis
A1 - Xi-ping ZHANG
A1 - Han-qing CHEN
A1 - Fang LIU
A1 - Jie ZHANG
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 7
SP - 493
EP - 498
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820265


Abstract: 
During the development and progression of severe acute pancreatitis (SAP), conspicuous immune dysregulation develops, which is mainly manifested as excessive immune response in the early stage and immunosuppression in the late stage. This process involves complex changes in a variety of immune molecules and cells, such as cytokines, complements, lymphocytes, and leukocytes. With the gradual deepening of studies on the development and progression of SAP, the role of immune dysregulation in the pathogenesis of SAP has attracted more and more attention. In this article, we review the advances in research on the immune dysregulation in SAP and the immunotherapy of this disease through exploring the formation of excessive immune response and immune suppression as well as their mutual transformation.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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