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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.11 P.833~838

http://doi.org/10.1631/jzus.B0820362


CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality


Author(s):  Hua-feng WANG, Yi-zhi CHENG, Huan-ping WANG, Zhi-mei CHEN, Ji-yu LOU, Jie JIN

Affiliation(s):  Department of Hematology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   jiej@hzcnc.com

Key Words:  Trisomy 21, Acute myeloid leukemia, Cluster of differentiation 19 (CD19)


Hua-feng WANG, Yi-zhi CHENG, Huan-ping WANG, Zhi-mei CHEN, Ji-yu LOU, Jie JIN. CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality[J]. Journal of Zhejiang University Science B, 2009, 10(11): 833~838.

@article{title="CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality",
author="Hua-feng WANG, Yi-zhi CHENG, Huan-ping WANG, Zhi-mei CHEN, Ji-yu LOU, Jie JIN",
journal="Journal of Zhejiang University Science B",
volume="10",
number="11",
pages="833~838",
year="2009",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820362"
}

%0 Journal Article
%T CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality
%A Hua-feng WANG
%A Yi-zhi CHENG
%A Huan-ping WANG
%A Zhi-mei CHEN
%A Ji-yu LOU
%A Jie JIN
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 11
%P 833~838
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820362

TY - JOUR
T1 - CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality
A1 - Hua-feng WANG
A1 - Yi-zhi CHENG
A1 - Huan-ping WANG
A1 - Zhi-mei CHEN
A1 - Ji-yu LOU
A1 - Jie JIN
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 11
SP - 833
EP - 838
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820362


Abstract: 
We report that a 63-year-old Chinese female had acute myeloblastic leukemia (AML) in which trisomy 21 (+21) was found as the sole acquired karyotypic abnormality. The blasts were positive for myeloperoxidase, and the immunophenotype was positive for cluster of differentiation 19 (CD19), CD33, CD34, and human leukocyte antigens (HLA)-DR. The chromosomal analysis of bone marrow showed 47,XX,+21[2]/46,XX[18]. Fluorescent in situ hybridization (FISH) showed that three copies of AML1 were situated in separate chromosomes, and that t(8;21) was negative. The patient did not have any features of Down syndrome. A diagnosis of CD19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AML with trisomy 21 as the sole cytogenetic abnormality. The possible prognostic significance of the finding in AML with +21 as the sole acquired karyotypic abnormality was discussed.

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