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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.2 P.127-135

http://doi.org/10.1631/jzus.B0900232


Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations


Author(s):  Bo-feng ZHU, Guang YANG, Chun-mei SHEN, Hai-xia QIN, Shun-zhi LIU, Ya-jun DENG, Shuan-liang FAN, Li-bin DENG, Feng CHEN, Ping ZHANG, Jie FANG, Li-ping CHEN, Hong-dan WANG, Zhen-yuan WANG, Rudolf LUCAS

Affiliation(s):  Department of Forensic Medicine, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, China; more

Corresponding email(s):   gyang@mcg.edu, wzy218@mail.xjtu.edu.cn

Key Words:  Yi ethnic minority, Human leukocyte antigen (HLA)-A, HLA-B, Allele, Haplotype, Polymerase chain reaction-sequence-based typing (PCR-SBT)


Bo-feng ZHU, Guang YANG, Chun-mei SHEN, Hai-xia QIN, Shun-zhi LIU, Ya-jun DENG, Shuan-liang FAN, Li-bin DENG, Feng CHEN, Ping ZHANG, Jie FANG, Li-ping CHEN, Hong-dan WANG, Zhen-yuan WANG, Rudolf LUCAS. Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations[J]. Journal of Zhejiang University Science B, 2010, 11(2): 127-135.

@article{title="Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations",
author="Bo-feng ZHU, Guang YANG, Chun-mei SHEN, Hai-xia QIN, Shun-zhi LIU, Ya-jun DENG, Shuan-liang FAN, Li-bin DENG, Feng CHEN, Ping ZHANG, Jie FANG, Li-ping CHEN, Hong-dan WANG, Zhen-yuan WANG, Rudolf LUCAS",
journal="Journal of Zhejiang University Science B",
volume="11",
number="2",
pages="127-135",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0900232"
}

%0 Journal Article
%T Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations
%A Bo-feng ZHU
%A Guang YANG
%A Chun-mei SHEN
%A Hai-xia QIN
%A Shun-zhi LIU
%A Ya-jun DENG
%A Shuan-liang FAN
%A Li-bin DENG
%A Feng CHEN
%A Ping ZHANG
%A Jie FANG
%A Li-ping CHEN
%A Hong-dan WANG
%A Zhen-yuan WANG
%A Rudolf LUCAS
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 2
%P 127-135
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0900232

TY - JOUR
T1 - Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations
A1 - Bo-feng ZHU
A1 - Guang YANG
A1 - Chun-mei SHEN
A1 - Hai-xia QIN
A1 - Shun-zhi LIU
A1 - Ya-jun DENG
A1 - Shuan-liang FAN
A1 - Li-bin DENG
A1 - Feng CHEN
A1 - Ping ZHANG
A1 - Jie FANG
A1 - Li-ping CHEN
A1 - Hong-dan WANG
A1 - Zhen-yuan WANG
A1 - Rudolf LUCAS
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 2
SP - 127
EP - 135
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0900232


Abstract: 
Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the yi ethnic minority of the Yunnan Province, situated in southwestern China. Methods: DNA typing for HLA-A and -B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and -B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. Results: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A*2402 (32.46%), A*1101 (26.32%), and A*0203 (10.09%) at the HLA-A locus and B*4601 (12.28%), B*1525 (10.09%), B*4001 (8.77%), and B*3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A*2402-B*1525 (7.86%) and A*0203-B*3802 (5.64%), followed by A*1101-B*4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. Conclusion: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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