Full Text:   <4892>

CLC number: R392

On-line Access: 

Received: 2009-08-01

Revision Accepted: 2009-11-18

Crosschecked: 2010-01-07

Cited: 15

Clicked: 8111

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.2 P.127-135

http://doi.org/10.1631/jzus.B0900232


Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations


Author(s):  Bo-feng ZHU, Guang YANG, Chun-mei SHEN, Hai-xia QIN, Shun-zhi LIU, Ya-jun DENG, Shuan-liang FAN, Li-bin DENG, Feng CHEN, Ping ZHANG, Jie FANG, Li-ping CHEN, Hong-dan WANG, Zhen-yuan WANG, Rudolf LUCAS

Affiliation(s):  Department of Forensic Medicine, School of Medicine, Xian Jiaotong University, Xian 710061, China; more

Corresponding email(s):   gyang@mcg.edu, wzy218@mail.xjtu.edu.cn

Key Words:  Yi ethnic minority, Human leukocyte antigen (HLA)-A, HLA-B, Allele, Haplotype, Polymerase chain reaction-sequence-based typing (PCR-SBT)


Bo-feng ZHU, Guang YANG, Chun-mei SHEN, Hai-xia QIN, Shun-zhi LIU, Ya-jun DENG, Shuan-liang FAN, Li-bin DENG, Feng CHEN, Ping ZHANG, Jie FANG, Li-ping CHEN, Hong-dan WANG, Zhen-yuan WANG, Rudolf LUCAS. Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations[J]. Journal of Zhejiang University Science B, 2010, 11(2): 127-135.

@article{title="Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations",
author="Bo-feng ZHU, Guang YANG, Chun-mei SHEN, Hai-xia QIN, Shun-zhi LIU, Ya-jun DENG, Shuan-liang FAN, Li-bin DENG, Feng CHEN, Ping ZHANG, Jie FANG, Li-ping CHEN, Hong-dan WANG, Zhen-yuan WANG, Rudolf LUCAS",
journal="Journal of Zhejiang University Science B",
volume="11",
number="2",
pages="127-135",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0900232"
}

%0 Journal Article
%T Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations
%A Bo-feng ZHU
%A Guang YANG
%A Chun-mei SHEN
%A Hai-xia QIN
%A Shun-zhi LIU
%A Ya-jun DENG
%A Shuan-liang FAN
%A Li-bin DENG
%A Feng CHEN
%A Ping ZHANG
%A Jie FANG
%A Li-ping CHEN
%A Hong-dan WANG
%A Zhen-yuan WANG
%A Rudolf LUCAS
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 2
%P 127-135
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0900232

TY - JOUR
T1 - Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations
A1 - Bo-feng ZHU
A1 - Guang YANG
A1 - Chun-mei SHEN
A1 - Hai-xia QIN
A1 - Shun-zhi LIU
A1 - Ya-jun DENG
A1 - Shuan-liang FAN
A1 - Li-bin DENG
A1 - Feng CHEN
A1 - Ping ZHANG
A1 - Jie FANG
A1 - Li-ping CHEN
A1 - Hong-dan WANG
A1 - Zhen-yuan WANG
A1 - Rudolf LUCAS
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 2
SP - 127
EP - 135
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0900232


Abstract: 
Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and -B alleles and HLA-A-B haplotypes in the yi ethnic minority of the Yunnan Province, situated in southwestern China. Methods: DNA typing for HLA-A and -B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and -B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. Results: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A*2402 (32.46%), A*1101 (26.32%), and A*0203 (10.09%) at the HLA-A locus and B*4601 (12.28%), B*1525 (10.09%), B*4001 (8.77%), and B*3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A*2402-B*1525 (7.86%) and A*0203-B*3802 (5.64%), followed by A*1101-B*4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. Conclusion: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Allen, M., Saldeen, T., Pettersson, U., Gyllensten, U., 1993. Genetic typing of HLA class II genes in Swedish populations: application to forensic analysis. Journal of Forensic Science, 38(3):554-570.

[2] Cao, K., Hollenbach, J., Shi, X., Shi, W., Chopek, M., Fernández-Viña, M.A., 2001. Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations. Human Immunology, 62(9):1009-1030.

[3] Cao, K., Moormann, A.M., Lyke, K.E., Masaberg, C., Sumba, O.P., Doumbo, O.K., Koech, D., Lancaster, A., Nelson, M., Meyer, D., et al., 2004. Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci. Tissue Antigens, 63(4):293-325.

[4] Chen, S., Hong, W., Shao, H., Fu, Y., Liu, X., Chen, D., Xu, A., 2006. Allelic distribution of HLA class I genes in the Tibetan ethnic population of China. International Journal of Immunogenetics, 33(6):439-445.

[5] Chen, S., Ren, X., Liu, Y., Hu, Q., Hong, W., Xu, A., 2007. Human leukocyte antigen class I polymorphism in Miao, Bouyei, and Shui ethnic minorities of Guizhou, China. Human Immunology, 68(11):928-933.

[6] Chen, W.M., Huang, H.L., Liu, Z.H., Tao, H., Pan, D.J., Lin, J.H., Xu, A.L., 2001. Analysis of HLA-DQB1 polymorphism by PCR-SSO in Yichu of Yunnan Province. Yi Chuan Xue Bao, 28(2):107-114 (in Chinese).

[7] China, National Bureau of Statistics, 2001. Chinese Statistical Yearbook 2000. China Statistics Press, Beijing, China, p. 415-416 (in Chinese).

[8] Chung, W.H., Hung, S.I., Hong, H.S., Hsih, M.S., Yang, L.C., Ho, H.C., Wu, J.Y., Chen, Y.T., 2004. Medical genetics: a marker for Stevens-Johnson syndrome. Nature, 428(6982):486.

[9] Danzer, M., Polin, H., Pröll, J., Hofer, K., Fae, I., Fischer, G.F., Gabriel, C., 2007. High-throughput sequence-based typing strategy for HLA-DRB1 based on real-time polymerase chain reaction. Human Immunology, 68(11):915-917.

[10] Du, R., Xiao, C., Cavalli-sforza, L.L., 1997. Genetic distances between Chinese populations calculated on gene frequencies of 38 loci. Science in China Series C, Life Sciences, 40(6):613-621 (in Chinese).

[11] Dunne, C., Crowley, J., Hagan, R., Rooney, G., Lawlor, E., 2008. HLA-A, B, Cw, DRB1, DQB1 and DPB1 alleles and haplotypes in the genetically homogenous Irish population. International Journal of Immunogenetics, 35(4-5):295-302.

[12] Erlich, H.A., Opelz, G., Hansen, J., 2001. HLA DNA typing and transplantation. Immunity, 14(4):347-356.

[13] Excoffier, L., Laval, G., Schneider, S., 2005. Arlequin (version 3.0): an integrated software package for population genetics data analysis. Evolutionary Bioinformatics Online, 1:47-50.

[14] Guo, D.L., Dong, J.Z., 2000. Summarization of Chinese Nationalities (Zhonghua Mingzu Zhishi Tonglan). Kunming Education Publishing House, Kunming, China, p.86-94 (in Chinese).

[15] Guo, S.W., Thompson, E.A., 1992. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics, 48(2):361-372.

[16] Hoa, B.K., Hang, N.T., Kashiwase, K., Ohashi, J., Lien, L.T., Horie, T., Shojima, J., Hijikata, M., Sakurada, S., Satake, M., et al., 2008. HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in the Kinh population in Vietnam. Tissue Antigens, 71(2):127-134.

[17] Hong, W., Chen, S., Shao, H., Fu, Y., Hu, Z., Xu, A., 2007. HLA class I polymorphism in Mongolian and Hui ethnic groups from Northern China. Human Immunology, 68(5):439-448.

[18] Hu, S.P., Luan, J.A., Li, B., Chen, J.X., Cai, K.L., Huang, L.Q., Xu, X.Y., 2007. Genetic link between Chaoshan and other Chinese Han populations: evidence from HLA-A and HLA-B allele frequency distribution. American Journal of Physical Anthropology, 132(1):140-150.

[19] Hung, S.I., Chung, W.H., Jee, S.H., Chen, W.C., Chang, Y.T., Lee, W.R., Hu, S.L., Wu, M.T., Chen, G.S., Wong, T.W., et al., 2006. Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenetics and Genomics, 16(4):297-306.

[20] Jiang, B., Li, Y., Wu, H., He, X.M., Li, C.T., Li, L., Tang, R., Xie, Y., Mao, Y.M., 2006. Application of HLA-DRB1 genotyping by oligonucleotide micro-array technology in forensic medicine. Forensic Science International, 162(1-3):66-73.

[21] Kurz, B., Steiert, I., Heuchert, G., Müller, C.A., 1999. New high resolution typing strategy for HLA-A locus alleles based on dye terminator sequencing of haplotypic group-specific PCR-amplicons of exon 2 and exon 3. Tissue Antigens, 53(1):81-96.

[22] Lee, H.C., Ladd, C., Bourke, M.T., Pagliaro, E., Tirnady, F., 1994. DNA typing in forensic science. I. Theory and background. The American Journal of Forensic Medicine and Pathology, 15(4):269-282.

[23] Lee, K.W., Oh, D.H., Lee, C., Yang, S.Y., 2005. Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population. Tissue Antigens, 65(5):437-447.

[24] Li, L., Li, C.T., Liu, Y., 2004. Research on the application feasibility of HLA-DRB1 genotyping for forensic identification by oligonucleotide chip. Fa Yi Xue Za Zhi, 20(2):81-84, 87 (in Chinese).

[25] Li, Y., Yan, H., Xue, W.J., Tian, P.X., Ding, X.M., Pan, X.M., Feng, X.S., Tian, X.H., Xiang, H.L., Hou, J., 2009. Allograft rejection-related gene expression in the endothelial cells of renal transplantation recipients after cytomegalovirus infection. Journal of Zhejiang University-SCIENCE B, 10(11):820-828.

[26] Lin, M., Tseng, H.K., Trejaut, J.A., Lee, H.L., Loo, J.H., Chu, C.C., Chen, P.J., Su, Y.W., Lim, K.H., Tsai, Z.U., et al., 2003. Association of HLA class I with severe acute respiratory syndrome coronavirus infection. BMC Medical Genetics, 4(1):9.

[27] Lo, Y.M., Patel, P., Mehal, W.Z., Fleming, K.A., Bell, J.I., Wainscoat, J.S., 1992. Analysis of complex genetic systems by ARMS-SSCP: application to HLA genotyping. Nucleic Acids Research, 20(5):1005-1009.

[28] Lonjou, C., Thomas, L., Borot, N., Ledger, N., de Toma, C., LeLouet, H., Graf, E., Schumacher, M., Hovnanian, A., Mockenhaupt, M., et al., 2006. A marker for Stevens-Johnson syndrome ...: ethnicity matters. The Pharmacogenomics Journal, 6(4):265-268.

[29] Lu, X.Z., Hong, K.X., Qin, G.M., Li, C.X., Zhu, J.H., Shao, Y.M., 2003a. DNA typing of HLA-A locus in Chinese Yi ethnic group by PCR-SSP. Immunological Journal, 19(6):2 (in Chinese).

[30] Lu, X.Z., Hong, K.X., Qin, G.M., Chen, J.P., Ruan, Y.H., Li, C.H., Zhu, J.H., Shao, Y.M., 2003b. Genotyping of HLA-Cw locus in Chinese Yi ethnic group by PCR-SSP. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 17(1):62-65 (in Chinese).

[31] Mack, S.J., Tu, B., Lazaro, A., Yang, R., Lancaster, A.K., Cao, K., Ng, J., Hurley, C.K., 2009. HLA-A, -B, -C, and -DRB1 allele and haplotype frequencies distinguish eastern European Americans from the general European American population. Tissue Antigens, 73(1):17-32.

[32] Man, C.B., Kwan, P., Baum, L., Yu, E., Lau, K.M., Cheng, A.S., Ng, M.H., 2007. Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. Epilepsia, 48(5):1015-1018.

[33] Marsh, S.G., Albert, E.D., Bodmer, W.F., Bontrop, R.E., Dupont, B., Erlich, H.A., Geraghty, D.E., Hansen, J.A., Mach, B., Mayr, W.R., et al., 2002. Nomenclature for factors of the HLA system, 2002. European Journal of Immunogenetics, 29(6):463-515.

[34] Mayr, W.R., 1988. The detection of HLA antigens in bloodstains. Zeitschrift für Rechtsmedizin. Journal of Legal Medicine, 101(4):209-217.

[35] Middleton, D., Hawkins, B.R., Williams, F., Meenagh, A., Moscoso, J., Zamora, J., Arnaiz-Villena, A., 2004. HLA class I allele distribution of a Hong Kong Chinese population based on high-resolution PCR-SSOP typing. Tissue Antigens, 63(6):555-561.

[36] Miller, S.A., Dykes, D.D., Polesky, H.F., 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Research, 16(3):1215.

[37] Mullis, K.B., Faloona, F.A., 1987. Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods in Enzymology, 155:335-350.

[38] Ogata, S., Shi, L., Matsushita, M., Yu, L., Huang, X.Q., Shi, L., Sun, H., Ohashi, J., Muramatsu, M., Tokunaga, K., et al., 2007. Polymorphisms of human leucocyte antigen genes in Maonan people in China. Tissue Antigens, 69(2):154-160.

[39] Petersdorf, E.W., Smith, A.G., Haase, A.M., Martin, P.J., Hansen, J.A., 1991. Polymorphism of HLA-DRw52-associated DRB1 genes as defined by sequence-specific oligonucleotide probe hybridization and sequencing. Tissue Antigens, 38(4):169-177.

[40] Pozzi, S., Longo, A., Ferrara, G.B., 1999. HLA-B locus sequence-based typing. Tissue Antigens, 53(3):275-281.

[41] Saito, S., Ota, S., Yamada, E., Inoko, H., Ota, M., 2000. Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population. Tissue Antigens, 56(6):522-529.

[42] Santamaria, P., Lindstrom, A.L., Boyce-Jacino, M.T., Myster, S.H., Barbosa, J.J., Faras, A.J., Rich, S.S., 1993. HLA class I sequence-based typing. Human Immunology, 37(1):39-50.

[43] Scheltinga, S.A., Johnston-Dow, L.A., White, C.B., van der Zwan, A.W., Bakema, J.E., Rozemuller, E.H., van den Tweel, J.G., Kronick, M.N., Tilanus, M.G., 1997. A generic sequencing based typing approach for the identification of HLA-A diversity. Human Immunology, 57(2):120-128.

[44] Shen, C.M., Zhu, B.F., Liu, M.L., Li, S.B., 2008. Genetic polymorphisms at HLA-A, -B, and -DRB1 loci in Han population of Xi’an city in China. Croatian Medical Journal, 49(4):476-482.

[45] Shi, L., Ogata, S., Yu, J.K., Ohashi, J., Yu, L., Shi, L., Sun, H., Lin, K., Huang, X.Q., Matsushita, M., et al., 2008. Distribution of HLA alleles and haplotypes in Jinuo and Wa populations in Southwest China. Human Immunology, 69(1):58-65.

[46] Shi, M., Bai, R., Wan, L., Yu, X., Chang, L., 2008. Population genetics for Y-chromosomal STRs haplotypes of Chinese Tujia ethnic group. Forensic Science International Genetics, 2(4):e65-e68.

[47] Single, R.M., Meyer, D., Hollenbach, J.A., Nelson, M.P., Noble, J.A., Erlich, H.A., Thomson, G., 2002. Haplotype frequency estimation in patient populations: the effect of departures from Hardy-Weinberg proportions and collapsing over a locus in the HLA region. Genetic Epidemiology, 22(2):186-195.

[48] Spínola, H., Brehm, A., Bettencourt, B., Middleton, D., Bruges-Armas, J., 2005a. HLA class I and II polymorphisms in Azores show different settlements in Oriental and Central islands. Tissue Antigens, 66(3):217-230.

[49] Spínola, H., Middleton, D., Brehm, A., 2005b. HLA genes in Portugal inferred from sequence-based typing: in the crossroad between Europe and Africa. Tissue Antigens, 66(1):26-36.

[50] Takeshima, S.N., Matsumoto, Y., Aida, Y., 2009. Short communication: establishment of a new polymerase chain reaction-sequence-based typing method for genotyping cattle major histocompatibility complex class II DRB3. Journal of Dairy Science, 92(6):2965-2970.

[51] Tereba, A., 1999. Tools for analysis of population statistics. Profiles DNA, 2:3.

[52] Trachtenberg, E., Vinson, M., Hayes, E., Hsu, Y.M., Houtchens, K., Erlich, H., Klitz, W., Hsia, Y., Hollenbach, J., 2007. HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China. Tissue Antigens, 70(6):455-463.

[53] Wang, H.F., Cheng, Y.Z., Wang, H.P., Chen, Z.M., Lou, J.Y., Jin, J., 2009. CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality. Journal of Zhejiang University-SCIENCE B, 10(11):833-838.

[54] Weir, B.S., 1996. Genetic Data Analysis II: Methods for Discrete Population Genetic Data. Sinauer Associates Inc., Sunderland, Massachusetts, United States, p.204-206.

[55] Wen, G., Huang, Y., Hao, P., Qi, Q., Li, H., Zhou, L., Zhou, L., Yu, L., 2004. Analysis of HLA-DRB1, DQB1 allele polymorphism in the Kunming Yi nationality population. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 21(5):522-523 (in Chinese).

[56] Wen, S.H., Lai, M.J., Yang, K.L., 2008. Human leukocyte antigen-A, -B, and -DRB1 haplotypes of cord blood units in the Tzu Chi Taiwan Cord Blood Bank. Human Immunology, 69(7):430-436.

[57] Xu, M.Y., Hong, K.X., Ma, J., Deng, X.L., Li, J., Peng, H., Ruan, Y.H., Qin, G.M., Zhang, Y.Z., Xing, H., et al., 2006. Analysis of HLA-B locus gene polymorphism in Sichuan Yi ethnic group and Xinjiang Uygur ethnic group. Yi Chuan, 28(8):913-917 (in Chinese).

[58] Yang, G., Deng, Y.J., Hu, S.N., Wu, D.Y., Li, S.B., Zhu, J., Zhu, B.F., Liu, Y., 2006. HLA-A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China. Tissue Antigens, 67(2):146-152.

[59] Yang, Z.L., Guo, Y., Gao, L., Wang, Y., Dong, Y.L., Tang, W.R., Li, K.Y., Yan, W., Xiao, C.J., 2004. Hypertension survey in Yi ethnic group in Yunnan Province, China. Zhonghua Liu Xing Bing Xue Za Zhi, 25(9):817 (in Chinese).

[60] Yuliwulandari, R., Kashiwase, K., Nakajima, H., Uddin, J., Susmiarsih, T.P., Sofro, A.S., Tokunaga, K., 2009. Polymorphisms of HLA genes in western Javanese (Indonesia): close affinities to Southeast Asian populations. Tissue Antigens, 73(1):46-53.

[61] Zetterquist, H., Olerup, O., 1992. Identification of the HLA-DRB1*04, -DRB1*07, and -DRB1*09 alleles by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours. Human Immunology, 34(1):64-74.

[62] Zhu, B.F., Shen, C.M., Wu, Q.J., Deng, Y.J., 2008. Population data of 15 STR loci of Chinese Yi ethnic minority group. Legal Medicine (Tokyo), 10(4):220-224.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE