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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.2 P.102-108

http://doi.org/10.1631/jzus.B0900288


Sodium tetrachloroaurate(III) dihydrate-catalyzed efficient synthesis of 1,5-benzodiazepine and quinoxaline derivatives


Author(s):  Ren-xin SHI, Yun-kui LIU, Zhen-yuan XU

Affiliation(s):  State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China

Corresponding email(s):   ykuiliu@zjut.edu.cn, greensyn@zjut.edu.cn

Key Words:  1, 5-benzodiaepines, o-phenylenediamine, Ketones, Quinoxalines, Gold catalyst


Ren-xin SHI, Yun-kui LIU, Zhen-yuan XU. Sodium tetrachloroaurate(III) dihydrate-catalyzed efficient synthesis of 1,5-benzodiazepine and quinoxaline derivatives[J]. Journal of Zhejiang University Science B, 2010, 11(2): 102-108.

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author="Ren-xin SHI, Yun-kui LIU, Zhen-yuan XU",
journal="Journal of Zhejiang University Science B",
volume="11",
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pages="102-108",
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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0900288"
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%T Sodium tetrachloroaurate(III) dihydrate-catalyzed efficient synthesis of 1,5-benzodiazepine and quinoxaline derivatives
%A Ren-xin SHI
%A Yun-kui LIU
%A Zhen-yuan XU
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 2
%P 102-108
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0900288

TY - JOUR
T1 - Sodium tetrachloroaurate(III) dihydrate-catalyzed efficient synthesis of 1,5-benzodiazepine and quinoxaline derivatives
A1 - Ren-xin SHI
A1 - Yun-kui LIU
A1 - Zhen-yuan XU
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 2
SP - 102
EP - 108
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0900288


Abstract: 
Both 1,5-benzodiazepine and quinoxaline derivatives are important heterocycles in pharmaceuticals. We describe an efficient and clean method for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones catalyzed by sodium tetrachloroaurate(III) dihydrate under mild conditions. The catalyst was shown to be equally effective for the synthesis of quinoxalines from o-phenylenediamine and α-bromo ketones under the similar reaction conditions. This method produced good yields.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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