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CLC number: R75

On-line Access: 2010-01-01

Received: 2009-09-24

Revision Accepted: 2009-11-23

Crosschecked: 2009-12-04

Cited: 5

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.1 P.1-9

http://doi.org/10.1631/jzus.B0900295


Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy


Author(s):  Ching-hung LIN, Huang-chun LIEN, Fu-chang HU, Yen-shen LU, Sung-hsin KUO, Ling-chu WU, San-lin YOU, Ann-lii CHENG, King-jen CHANG, Chiun-sheng HUANG

Affiliation(s):  Department of Oncology, National Taiwan University Hospital, Taiwan, Taipei 10016; more

Corresponding email(s):   huangcs@ntu.edu.tw

Key Words:  Breast cancer, Fractionated evaluation, Estrogen receptor, Progesterone receptor


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Ching-hung LIN, Huang-chun LIEN, Fu-chang HU, Yen-shen LU, Sung-hsin KUO, Ling-chu WU, San-lin YOU, Ann-lii CHENG, King-jen CHANG, Chiun-sheng HUANG. Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy[J]. Journal of Zhejiang University Science B, 2010, 11(1): 1-9.

@article{title="Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy",
author="Ching-hung LIN, Huang-chun LIEN, Fu-chang HU, Yen-shen LU, Sung-hsin KUO, Ling-chu WU, San-lin YOU, Ann-lii CHENG, King-jen CHANG, Chiun-sheng HUANG",
journal="Journal of Zhejiang University Science B",
volume="11",
number="1",
pages="1-9",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0900295"
}

%0 Journal Article
%T Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy
%A Ching-hung LIN
%A Huang-chun LIEN
%A Fu-chang HU
%A Yen-shen LU
%A Sung-hsin KUO
%A Ling-chu WU
%A San-lin YOU
%A Ann-lii CHENG
%A King-jen CHANG
%A Chiun-sheng HUANG
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 1
%P 1-9
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0900295

TY - JOUR
T1 - Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy
A1 - Ching-hung LIN
A1 - Huang-chun LIEN
A1 - Fu-chang HU
A1 - Yen-shen LU
A1 - Sung-hsin KUO
A1 - Ling-chu WU
A1 - San-lin YOU
A1 - Ann-lii CHENG
A1 - King-jen CHANG
A1 - Chiun-sheng HUANG
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 1
SP - 1
EP - 9
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0900295


Abstract: 
Objective: To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions. Methods: Patients with stages I–III breast cancers, who received adjuvant tamoxifen, were enrolled. The expression of estrogen receptor (ER) and progesterone receptor (PR) was evaluated by immunohistochemistry (IHC). A fractionated score (F score), the percentage of positive-staining nuclei (0=none, 1=1%–10%, 2=11%–30%, 3=31%–50%, 4=51%–70%, and 5=71%–100%), was assigned to each case. The dichotomized scoring method defines an F score >1 as positive. The prognostic values of both scores were compared by multiple Cox’s proportional hazard models of disease-free survival (DFS) and overall survival (OS). Results: Four hundred and sixteen patients with a median follow-up of 78.0 months were included. F scores for ER and PR correlated directly with DFS and OS. Although both the dichotomized and fractionated ER and PR scores were significantly associated with DFS and OS in univariate analyses, only fractionated ER and PR scores remained as independent prognostic factors of DFS and OS in the final multiple Cox’s proportional hazard models. Conclusion: Fractionated IHC hormone receptor expression evaluation enhances the prognostic prediction compared with a dichotomized assessment.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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