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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.1 P.12-17

http://doi.org/10.1631/jzus.B1000106


Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy


Author(s):  Barbara Ruszkowska, Grażyna Gadomska, Liliana Bielis, Marzena Gruszka, Barbara Góralczyk, Danuta Rość, Grażyna Odrowąż-Sypniewska

Affiliation(s):  Department of Pathophysiology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, st. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland, Department of Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, st. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland

Corresponding email(s):   ruszkowska.basia@gmail.com

Key Words:  Menopause, Coagulation, Hormone replacement therapy


Barbara Ruszkowska, Grażyna Gadomska, Liliana Bielis, Marzena Gruszka, Barbara Góralczyk, Danuta Rość, Grażyna Odrowąż-Sypniewska. Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy[J]. Journal of Zhejiang University Science B, 2011, 12(1): 12-17.

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author="Barbara Ruszkowska, Grażyna Gadomska, Liliana Bielis, Marzena Gruszka, Barbara Góralczyk, Danuta Rość, Grażyna Odrowąż-Sypniewska",
journal="Journal of Zhejiang University Science B",
volume="12",
number="1",
pages="12-17",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000106"
}

%0 Journal Article
%T Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy
%A Barbara Ruszkowska
%A Grażyna Gadomska
%A Liliana Bielis
%A Marzena Gruszka
%A Barbara Góralczyk
%A Danuta Rość
%A Grażyna Odrowąż-Sypniewska
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 1
%P 12-17
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000106

TY - JOUR
T1 - Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy
A1 - Barbara Ruszkowska
A1 - Grażyna Gadomska
A1 - Liliana Bielis
A1 - Marzena Gruszka
A1 - Barbara Góralczyk
A1 - Danuta Rość
A1 - Grażyna Odrowąż-Sypniewska
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 1
SP - 12
EP - 17
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000106


Abstract: 
Objective: The influence of hormone replacement therapy (HRT) on hemostasis processes depends on the type of hormone, the combination of doses, the time of taking HRT, and the route of administration (oral, transdermal, implanted). The aim of the current study was to assess some parameters of coagulation, especially tissue factor pathway inhibitor (TFPI) and tissue factor (TF) in postmenopausal women using oral or transdermal HRT. Methods: The study was conducted on 76 healthy women, including 46 women aged 44–58 years who were taking oral (26) or transdermal (20) HRT, and 30 women aged 44–54 years who did not take HRT as the control group. Plasma concentrations of TF, TFPI, thrombin-antithrombin complex (TAT), and D-dimer were performed by enzyme-linked immunosorbent assay (ELISA). Moreover, the concentration of fibrinogen and activity of protein C were measured by chromogenic and chronometric methods. Results: We observed a significantly higher concentration of TF and a significantly lower concentration of TFPI in women taking oral and transdermal HRT in comparison with the control group. We also found a significantly lower concentration of fibrinogen in women taking oral HRT vs. the control group. Moreover, no statistically significant changes in concentrations of TAT and D-dimer, or activity of protein C were noted. Conclusions: In this study, the occurrence of an increased TF concentration simultaneously with a decreased concentration of TFPI in women taking HRT indicates hypercoagulability. No significant modification of TAT or D-dimer occurred, and thus there may not be increased risk of thrombosis.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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