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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.11 P.842-847

http://doi.org/10.1631/jzus.B1000200


Pure word deafness associated with extrapontine myelinolysis


Author(s):  Ren-jing Zhu, Zhi-su Lv, Chun-lei Shan, Ming-wei Xu, Ben-yan Luo

Affiliation(s):  Department of Neurology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310029, China, Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen 361004, China, Department of Ultrasonography, Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310029, China, Laboratory for Higher Brain Function, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China, Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Corresponding email(s):   luobenyan@zju.edu.cn

Key Words:  Pure word deafness, Auditory agnosia, Osmotic demyelination syndrome, Extrapontine myelinolysis, Cortical deafness


Ren-jing Zhu, Zhi-su Lv, Chun-lei Shan, Ming-wei Xu, Ben-yan Luo. Pure word deafness associated with extrapontine myelinolysis[J]. Journal of Zhejiang University Science B, 2010, 11(11): 842-847.

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author="Ren-jing Zhu, Zhi-su Lv, Chun-lei Shan, Ming-wei Xu, Ben-yan Luo",
journal="Journal of Zhejiang University Science B",
volume="11",
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pages="842-847",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000200"
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%T Pure word deafness associated with extrapontine myelinolysis
%A Ren-jing Zhu
%A Zhi-su Lv
%A Chun-lei Shan
%A Ming-wei Xu
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%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000200

TY - JOUR
T1 - Pure word deafness associated with extrapontine myelinolysis
A1 - Ren-jing Zhu
A1 - Zhi-su Lv
A1 - Chun-lei Shan
A1 - Ming-wei Xu
A1 - Ben-yan Luo
J0 - Journal of Zhejiang University Science B
VL - 11
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SP - 842
EP - 847
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000200


Abstract: 
extrapontine myelinolysis and pure word deafness are very uncommon disorders. Here, we report a case of a 19-year-old woman who suffered from osmotic demyelination syndrome with coincidence of typical pure word deafness. As a consequence of rapid correction of hyponatremia, the patient demonstrated an initial onset of cortical deafness, and then progressed to generalized auditory agnosia, which eventually developed into confined verbal auditory agnosia (pure word deafness). Bilateral extrapontine myelinolysis was confirmed using brain magnetic resonance imaging. This case suggests that verbal and nonverbal stimuli may involve separate thalamocortical pathways.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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