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CLC number: R692.6

On-line Access: 2011-11-30

Received: 2011-02-04

Revision Accepted: 2011-07-05

Crosschecked: 2011-11-16

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.12 P.1024-1033

http://doi.org/10.1631/jzus.B1100034


Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model


Author(s):  Rong Zhu, Yi-ping Chen, Yue-yi Deng, Rong Zheng, Yi-fei Zhong, Lin Wang, Lan-ping Du

Affiliation(s):  Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

Corresponding email(s):   lhkidney_cyp@hotmail.com, lhkidney@hotmail.com

Key Words:  Chronic kidney disease, Cordyceps cicadae, TGF-β


Rong Zhu, Yi-ping Chen, Yue-yi Deng, Rong Zheng, Yi-fei Zhong, Lin Wang, Lan-ping Du. Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model[J]. Journal of Zhejiang University Science B, 2011, 12(12): 1024-1033.

@article{title="Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model",
author="Rong Zhu, Yi-ping Chen, Yue-yi Deng, Rong Zheng, Yi-fei Zhong, Lin Wang, Lan-ping Du",
journal="Journal of Zhejiang University Science B",
volume="12",
number="12",
pages="1024-1033",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100034"
}

%0 Journal Article
%T Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model
%A Rong Zhu
%A Yi-ping Chen
%A Yue-yi Deng
%A Rong Zheng
%A Yi-fei Zhong
%A Lin Wang
%A Lan-ping Du
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 12
%P 1024-1033
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100034

TY - JOUR
T1 - Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model
A1 - Rong Zhu
A1 - Yi-ping Chen
A1 - Yue-yi Deng
A1 - Rong Zheng
A1 - Yi-fei Zhong
A1 - Lin Wang
A1 - Lan-ping Du
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 12
SP - 1024
EP - 1033
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100034


Abstract: 
Background and Objectives: chronic kidney disease (CKD) is a growing public health problem with an urgent need for new pharmacological agents. Cordyceps cicadae is widely used in traditional Chinese medicine (TCM) and has potential renoprotective benefits. The current study aimed to determine any scientific evidence to support its clinical use. Methods: We analyzed the potential of two kinds of C. cicadae extract, total extract (TE) and acetic ether extract (AE), in treating kidney disease simulated by a subtotal nephrectomy (SNx) model. Sprague-Dawley rats were divided randomly into seven groups: sham-operated group, vehicle-treated SNx, Cozaar, 2 g/(kg∙d) TE SNx, 1 g/(kg∙d) TE SNx, 92 mg/(kg∙d) AE SNx, and 46 mg/(kg∙d) AE SNx. Renal injury was monitored using urine and serum analyses, and hematoxylin and eosin (HE) and periodic acid-Schiff (PAS) stainings were used to analyze the level of fibrosis. The expression of type IV collagen (Col IV), fibronectin (FN), transforming growth factor-β1 (TGF-β;1), and connective tissue growth factor (CTGF) was detected by immunohistochemistry. Results: Renal injury, reflected in urine and serum analyses, and pathological changes induced by SNx were attenuated by TE and AE intervention. The depositions of Col IV and FN were also decreased by the treatments and were accompanied by reduced expression of TGF-β;1 and CTGF. In some respects, 2 g/(kg∙d) of TE produced better effects than Cozaar. Conclusions: For the first time, we have shown that C. cicadae may inhibit renal fibrosis in vivo through the TGF-β;1/CTGF pathway. Therefore, we conclude that the use of C. cicadae could provide a rational strategy for combating renal fibrosis.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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