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CLC number: R737.31

On-line Access: 2011-10-08

Received: 2011-05-22

Revision Accepted: 2011-09-13

Crosschecked: 2011-08-29

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.10 P.787-795

10.1631/jzus.B1100166


Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma


Author(s):  Jun Hu, Li-rong Zhu, Zhi-qing Liang, Yuan-guang Meng, Hong-yan Guo, Peng-peng Qu, Cai-ling Ma, Cong-jian Xu, Bi-bo Yuan

Affiliation(s):  Department of Gynecology, Peking University First Hospital, Beijing 100034, China, Department of Gynecology, Southwest Hospital of Third Military Medical University, Chongqing 400038, China, Department of Gynecology, Chinese PLA General Hospital & Chinese PLA Postgraduate Medical School, Beijing 100853, China, Department of Gynecology, Peking University Third Hospital, Beijing 100191, China, Tianjin Central Obstetrics and Gynecological Hospital, Tianjin 300052, China, Department of Gynecology, Xinjiang Medical University First Teaching Hospital, Urumqi 830054, China, Shanghai Red House Hospital of Obstetrics and Gynecology, Shanghai 200011, China, Department of Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, China

Corresponding email(s):   Lirongzhu16@hotmail.com

Key Words:  Epithelial ovarian carcinoma, Fertility-sparing treatment, Overall survival, Disease-free survival, Pregnancy


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Jun Hu, Li-rong Zhu, Zhi-qing Liang, Yuan-guang Meng, Hong-yan Guo, Peng-peng Qu, Cai-ling Ma, Cong-jian Xu, Bi-bo Yuan. Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma[J]. Journal of Zhejiang University Science B, 2011, 12(10): 787-795.

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author="Jun Hu, Li-rong Zhu, Zhi-qing Liang, Yuan-guang Meng, Hong-yan Guo, Peng-peng Qu, Cai-ling Ma, Cong-jian Xu, Bi-bo Yuan",
journal="Journal of Zhejiang University Science B",
volume="12",
number="10",
pages="787-795",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100166"
}

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%A Zhi-qing Liang
%A Yuan-guang Meng
%A Hong-yan Guo
%A Peng-peng Qu
%A Cai-ling Ma
%A Cong-jian Xu
%A Bi-bo Yuan
%J Journal of Zhejiang University SCIENCE B
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%N 10
%P 787-795
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%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100166

TY - JOUR
T1 - Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma
A1 - Jun Hu
A1 - Li-rong Zhu
A1 - Zhi-qing Liang
A1 - Yuan-guang Meng
A1 - Hong-yan Guo
A1 - Peng-peng Qu
A1 - Cai-ling Ma
A1 - Cong-jian Xu
A1 - Bi-bo Yuan
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 10
SP - 787
EP - 795
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100166


Abstract: 
Objective: To assess the clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma (EOC). Methods: A retrospective study of young EOC inpatients (≤40 years old) was performed during January 1994 and December 2010 in eight institutions. Results: Data were analyzed from 94 patients treated with fertility-sparing surgery with a median follow-up time of 58.7 months. As histologic grade increased, overall survival (OS) and disease-free survival (DFS) of patients receiving fertility-sparing surgery declined. Neither staging surgery nor laparoscopy of early stage EOC with conservative surgery had a significant effect on OS or DFS. Normal menstruation recommenced after chemotherapy in 89% of the fertility-sparing group. Seventeen pregnancies among twelve patients were achieved by the end of the follow-ups. Conclusions: fertility-sparing treatment for patients with EOC Stage I Grade 1 could be cautiously considered for young patients. The surgical procedure and surgical route might not significantly influence the prognosis. Standard chemotherapy is not likely to have an evident impact on ovarian function or fertility in young patients.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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