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CLC number: R774.1

On-line Access: 2013-05-04

Received: 2012-09-03

Revision Accepted: 2012-10-27

Crosschecked: 2013-04-11

Cited: 4

Clicked: 2559

Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.5 P.392-399

10.1631/jzus.B1200237


Serum lipids and other risk factors for diabetic retinopathy in Chinese type 2 diabetic patients


Author(s):  Hui-yan Zhang, Jian-yong Wang, Gui-shuang Ying, Li-ping Shen, Zhe Zhang

Affiliation(s):  Hangzhou Vocational & Technical College, Hangzhou 310018, China; more

Corresponding email(s):   wangjianyong4@yahoo.com.cn

Key Words:  Diabetic retinopathy, Serum lipids, Risk factors


Hui-yan Zhang, Jian-yong Wang, Gui-shuang Ying, Li-ping Shen, Zhe Zhang. Serum lipids and other risk factors for diabetic retinopathy in Chinese type 2 diabetic patients[J]. Journal of Zhejiang University Science B, 2013, 14(5): 392-399.

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author="Hui-yan Zhang, Jian-yong Wang, Gui-shuang Ying, Li-ping Shen, Zhe Zhang",
journal="Journal of Zhejiang University Science B",
volume="14",
number="5",
pages="392-399",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1200237"
}

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%T Serum lipids and other risk factors for diabetic retinopathy in Chinese type 2 diabetic patients
%A Hui-yan Zhang
%A Jian-yong Wang
%A Gui-shuang Ying
%A Li-ping Shen
%A Zhe Zhang
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 5
%P 392-399
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200237

TY - JOUR
T1 - Serum lipids and other risk factors for diabetic retinopathy in Chinese type 2 diabetic patients
A1 - Hui-yan Zhang
A1 - Jian-yong Wang
A1 - Gui-shuang Ying
A1 - Li-ping Shen
A1 - Zhe Zhang
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 5
SP - 392
EP - 399
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200237


Abstract: 
Objective: To investigate the association of serum lipids and other risk factors with diabetic retinopathy (DR) in Chinese type 2 diabetic patients. Methods: Five hundred and twenty-three type 2 diabetic patients underwent ophthalmic examination by experienced retinal specialists to assess their DR. serum lipids, including triglycerides, total cholesterol, high density lipoprotein cholesterol (HDLC), and low density lipoprotein cholesterol (LDLC), were measured using Roche automated clinical chemistry analyzers. The concentration of very low density lipoprotein cholesterol (VLDLC) was calculated based on total cholesterol, HDLC and LDLC. Hyperlipidemia was defined as a total cholesterol concentration of 6.2 mmol/L or higher or the use of lipid-lowering medications. The association of risk factors with any DR or proliferative diabetic retinopathy (PDR) was assessed using the odds ratio (OR) and its 95% confidence interval (CI), calculated from logistic regression models. Results: In multivariate logistic regression models, hyperlipidemia (OR=2.39, 95% CI: 1.02–5.66), higher VLDLC (OR=1.59, 95% CI: 1.14–2.23), and higher triglyceride (OR=1.18, 95% CI: 1.03–1.37) were associated with increased risk of DR. A longer diabetic duration was associated with increased risk of DR (P<0.0001) and PDR (P=0.002) in a dose-response manner. Higher systolic blood pressure (P=0.02) and higher serum creatinine (P=0.01) were independently associated with increased risk of DR, and female gender was associated with increased risk of PDR (P=0.03). Conclusions: Among Chinese type 2 diabetic patients, hyperlipidemia, higher VLDLC, and higher triglyceride were independently associated with increased risk of DR, suggesting control of serum lipids may decrease the risk of DR.

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