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CLC number: R749.4

On-line Access: 2015-01-05

Received: 2014-06-17

Revision Accepted: 2014-11-06

Crosschecked: 2014-12-26

Cited: 11

Clicked: 6858

Citations:  Bibtex RefMan EndNote GB/T7714


Hui-yu ZHANG


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.62-69


Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice

Author(s):  Hui-yu Zhang, Yu-nan Zhao, Zhong-li Wang, Yu-fang Huang

Affiliation(s):  Laboratory of Pathological Sciences, Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China; more

Corresponding email(s):   huiyuzhang615@126.com, zhaoyunan-js@163.com

Key Words:  Glycogen, Corticosterone, Stress, Depression, Hippocampus

Hui-yu Zhang, Yu-nan Zhao, Zhong-li Wang, Yu-fang Huang. Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice[J]. Journal of Zhejiang University Science B, 2015, 16(1): 62-69.

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author="Hui-yu Zhang, Yu-nan Zhao, Zhong-li Wang, Yu-fang Huang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice
%A Hui-yu Zhang
%A Yu-nan Zhao
%A Zhong-li Wang
%A Yu-fang Huang
%J Journal of Zhejiang University SCIENCE B
%V 16
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%P 62-69
%@ 1673-1581
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400166

T1 - Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice
A1 - Hui-yu Zhang
A1 - Yu-nan Zhao
A1 - Zhong-li Wang
A1 - Yu-fang Huang
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 1
SP - 62
EP - 69
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400166

Long-term exposure to stress or high glucocorticoid levels leads to depression-like behavior in rodents; however, the cause remains unknown. Increasing evidence shows that astrocytes, the most abundant cells in the central nervous system (CNS), are important to the nervous system. Astrocytes nourish and protect the neurons, and serve as glycogen repositories for the brain. The metabolic process of glycogen, which is closely linked to neuronal activity, can supply sufficient energy substrates for neurons. The research team probed into the effects of chronic corticosterone (CORT) exposure on the glycogen level of astrocytes in the hippocampal tissues of male C57BL/6N mice in this study. The results showed that chronic CORT injection reduced hippocampal neurofilament light protein (NF-L) and synaptophysin (SYP) levels, induced depression-like behavior in male mice, reduced hippocampal glycogen level and glycogen synthase activity, and increased glycogen phosphorylase activity. The results suggested that the reduction of the hippocampal glycogen level may be the mechanism by which chronic CORT treatment damages hippocampal neurons and induces depression-like behavior in male mice.




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