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CLC number: R737.9; Q2

On-line Access: 2015-01-05

Received: 2014-08-11

Revision Accepted: 2014-11-06

Crosschecked: 2014-12-18

Cited: 33

Clicked: 4237

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Hua-feng ZHANG

http://orcid.org/0000-0001-9923-7531

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.32-43

http://doi.org/10.1631/jzus.B1400221


Hypoxia-inducible factor 1 and breast cancer metastasis


Author(s):  Zhao-ji Liu, Gregg L. Semenza, Hua-feng Zhang

Affiliation(s):  CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Biology, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; more

Corresponding email(s):   hzhang22@ustc.edu.cn

Key Words:  Breast cancer, Hypoxia-inducible factor 1 (HIF-1), Metastasis


Zhao-ji Liu, Gregg L. Semenza, Hua-feng Zhang. Hypoxia-inducible factor 1 and breast cancer metastasis[J]. Journal of Zhejiang University Science B, 2015, 16(1): 32-43.

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author="Zhao-ji Liu, Gregg L. Semenza, Hua-feng Zhang",
journal="Journal of Zhejiang University Science B",
volume="16",
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pages="32-43",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400221"
}

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%A Zhao-ji Liu
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%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400221

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T1 - Hypoxia-inducible factor 1 and breast cancer metastasis
A1 - Zhao-ji Liu
A1 - Gregg L. Semenza
A1 - Hua-feng Zhang
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EP - 43
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1400221


Abstract: 
Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes. In this review, we focus on the roles of HIF-1 in regulating breast cancer cell metastasis, specifically its effects on multiple key steps of metastasis, such as epithelial-mesenchymal transition (EMT), invasion, extravasation, and metastatic niche formation. We also discuss the roles of HIF-1-regulated non-coding RNAs in breast cancer metastasis, and therapeutic opportunities for breast cancer through targeting the HIF-1 pathway.

低氧诱导因子与乳腺癌转移

概要:肿瘤,特别是实体瘤,其内部微环境处于一种低氧或缺氧的状态,肿瘤的这种低氧微环境将诱导活化低氧诱导因子(HIF-1)信号通路。HIF-1信号通路在乳腺癌的转移中发挥着重要的作用。乳腺癌的转移涉及肿瘤细胞的浸润、进入血管、通过血液循环迁移、到达远端毛细血管内壁、穿透血管壁进入新的器官以及在新的部位形成转移灶等步骤,过程非常复杂。本文重点围绕HIF-1在转移各个步骤中的作用进行综述。

关键词:乳腺癌;低氧诱导因子;肿瘤转移

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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