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CLC number: R737.9; Q2

On-line Access: 2015-01-05

Received: 2014-08-11

Revision Accepted: 2014-11-06

Crosschecked: 2014-12-18

Cited: 33

Clicked: 4237

Citations:  Bibtex RefMan EndNote GB/T7714


Hua-feng ZHANG


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.32-43


Hypoxia-inducible factor 1 and breast cancer metastasis

Author(s):  Zhao-ji Liu, Gregg L. Semenza, Hua-feng Zhang

Affiliation(s):  CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Biology, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; more

Corresponding email(s):   hzhang22@ustc.edu.cn

Key Words:  Breast cancer, Hypoxia-inducible factor 1 (HIF-1), Metastasis

Zhao-ji Liu, Gregg L. Semenza, Hua-feng Zhang. Hypoxia-inducible factor 1 and breast cancer metastasis[J]. Journal of Zhejiang University Science B, 2015, 16(1): 32-43.

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DOI - 10.1631/jzus.B1400221

Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes. In this review, we focus on the roles of HIF-1 in regulating breast cancer cell metastasis, specifically its effects on multiple key steps of metastasis, such as epithelial-mesenchymal transition (EMT), invasion, extravasation, and metastatic niche formation. We also discuss the roles of HIF-1-regulated non-coding RNAs in breast cancer metastasis, and therapeutic opportunities for breast cancer through targeting the HIF-1 pathway.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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