CLC number: S81
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2015-05-13
Cited: 2
Clicked: 5347
Citations: Bibtex RefMan EndNote GB/T7714
Cun-xi Nie,Wen-ju Zhang,Yan-feng Liu,Wen-xia Ge,Jian-cheng Liu. Tissue lipid metabolism and hepatic metabolomic profiling in response to supplementation of fermented cottonseed meal in the diets of broiler chickens[J]. Journal of Zhejiang University Science B, 2015, 16(6): 447-455.
@article{title="Tissue lipid metabolism and hepatic metabolomic profiling in response to supplementation of fermented cottonseed meal in the diets of broiler chickens",
author="Cun-xi Nie,Wen-ju Zhang,Yan-feng Liu,Wen-xia Ge,Jian-cheng Liu",
journal="Journal of Zhejiang University Science B",
volume="16",
number="6",
pages="447-455",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400255"
}
%0 Journal Article
%T Tissue lipid metabolism and hepatic metabolomic profiling in response to supplementation of fermented cottonseed meal in the diets of broiler chickens
%A Cun-xi Nie
%A Wen-ju Zhang
%A Yan-feng Liu
%A Wen-xia Ge
%A Jian-cheng Liu
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 6
%P 447-455
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400255
TY - JOUR
T1 - Tissue lipid metabolism and hepatic metabolomic profiling in response to supplementation of fermented cottonseed meal in the diets of broiler chickens
A1 - Cun-xi Nie
A1 - Wen-ju Zhang
A1 - Yan-feng Liu
A1 - Wen-xia Ge
A1 - Jian-cheng Liu
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 6
SP - 447
EP - 455
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400255
Abstract: This study investigated the effects of fermented cottonseed meal (FCSM) on lipid metabolites, lipid metabolism-related gene expression in liver tissues and abdominal adipose tissues, and hepatic metabolomic profiling in broiler chickens. One hundred and eighty 21-d-old broiler chickens were randomly divided into three diet groups with six replicates of 10 birds in each group. The three diets consisted of a control diet supplemented with unfermented cottonseed meal, an experimental diet of cottonseed meal fermented by Candida tropicalis, and a second experimental diet of cottonseed meal fermented by C. tropicalis plus Saccharomyces cerevisae. The results showed that FCSM intake significantly decreased the levels of abdominal fat and hepatic triglycerides (P<0.05 for both). Dietary FCSM supplementation down-regulated the mRNA expression of fatty acid synthase and acetyl CoA carboxylase in liver tissues and the lipoprotein lipase expression in abdominal fat tissues (P<0.05 for both). FCSM intake resulted in significant metabolic changes of multiple pathways in the liver involving the tricarboxylic acid cycle, synthesis of fatty acids, and the metabolism of glycerolipid and amino acids. These findings indicated that FCSM regulated lipid metabolism by increasing or decreasing the expression of the lipid-related gene and by altering multiple endogenous metabolites. lipid metabolism regulation is a complex process, this discovery provided new essential information about the effects of FCSM diets in broiler chickens and demonstrated the great potential of nutrimetabolomics in researching complex nutrients added to animal diets.
[1]Aluwong, T., Hassan, F., Dzenda, T., et al., 2013. Effect of different levels of supplemental yeast on body weight, thyroid hormone metabolism and lipid profile of broiler chickens. J. Vet. Med. Sci., 75(3):291-298.
[2]An, Y., Xu, W., Li, H., et al., 2013. High-fat diet induces dynamic metabolic alterations in multiple biological matrices of rats. J. Proteome Res., 12(8):3755-3768.
[3]AOAC (Association of Official Analytical Chemists), 1999. Official Methods of Analysis, 16th Ed. AOAC, Washington, DC, USA.
[4]AOCS (American Oil Chemists Society ), 2009. Official Methods and Recommended Practices of the AOCS, 6th Ed. AOCS, Chicago, IL, USA.
[5]Cha, Y.S., Kim, S.R., Yang, J.A., et al., 2013. Kochujang, fermented soybean-based red pepper paste, decreases visceral fat and improves blood lipid profiles in overweight adults. Nutr. Metab., 10(1):24.
[6]de Genova Gaya, L., Mourão, G.B., de Rezende, F.M., et al., 2005. Genetic trends of abdominal fat content in a male broiler chicken line. Genet. Mol. Res., 4(4):760-764.
[7]Donohoe, D.R., Garge, N., Zhang, X., et al., 2011. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab., 13(5):517-526.
[8]Hausman, G.J., Dodson, M.V., Ajuwon, K., et al., 2009. Board-invited review: the biology and regulation of preadipocytes and adipocytes in meat animals. J. Anim. Sci., 87(4):1218-1246.
[9]He, Q., Ren, P., Kong, X., et al., 2012. Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabolomic approach. J. Nutr. Biochem., 23(2):133-139.
[10]Huang, J., Yang, D., Gao, S., et al., 2008. Effects of soy-lecithin on lipid metabolism and hepatic expression of lipogenic genes in broiler chickens. Livest. Sci., 118(1-2):53-60.
[11]Huber, M., van de Vijver, L.P.L., Parmentier, H., et al., 2010. Effects of organically and conventionally produced feed on biomarkers of health in a chicken model. Br. J. Nutr., 103(5):663-676.
[12]Ji, B., Ernest, B., Gooding, J.R., et al., 2012. Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fasting. BMC Genomics, 13(1):441.
[13]Joseph, S.B., Laffitte, B.A., Patel, P.H., et al., 2002. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J. Biol. Chem., 277(13):11019-11025.
[14]Khairallah, R.J., Kim, J., O'Shea, K.M., et al., 2012. Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. PLoS ONE, 7(3):e34402.
[15]Kim, H., Kim, J.H., Noh, S., et al., 2011. Metabolomic analysis of livers and serum from high-fat diet induced obese mice. J. Proteome Res., 10(2):722-731.
[16]Kind, T., Wohlgemuth, G., Lee, D.Y., et al., 2009. FiehnLib-mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. Anal. Chem., 81(24):10038-10048.
[17]Koh, J.H., Yu, K.W., Suh, H.J., 2002. Biological activities of Saccharomyces cerevisiae and fermented rice bran as feed additives. Lett. Appl. Microbiol., 35(1):47-51.
[18]Lee, S.S., Pineau, T., Drago, J., et al., 1995. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol., 15(6):3012-3022.
[19]Liu, G., Wang, Y., Wang, Z., et al., 2011. Nuclear magnetic resonance (NMR)-based metabolomic studies on urine and serum biochemical profiles after chronic cysteamine supplementation in rats. J. Agric. Food Chem., 59(10):5572-5578.
[20]Livak, K.J., Schmittgen, T.D., 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods, 25(4):402-408.
[21]Lukivskaya, O.Y., Maskevich, A.A., Buko, V.U., 2001. Effect of ursodeoxycholic acid on prostaglandin metabolism and microsomal membranes in alcoholic fatty liver. Alcohol, 25(2):99-105.
[22]Mandrup, S., Lane, M.D., 1997. Regulating adipogenesis. J. Biol. Chem., 272(9):5367-5370.
[23]Nie, C., Zhang, W., Yan, L., et al., 2013. A metabolomics study on chicken plasma based on fermented feed from cottonseed meal mixed substrate. Acta Vet. Zootech. Sin., 44(5):737-744 (in Chinese).
[24]Numa, S., Nakanishi, S., Hashimoto, T., et al., 1971. Role of acetyl coenzyme A carboxylase in the control of fatty acid synthesis. Vitam. Horm., 28:213-243.
[25]Oikawa, D., Tsuyama, S., Akimoto, Y., et al., 2009. Arachidonic acid prevents fatty liver induced by conjugated linoleic acid in mice. Br. J. Nutr., 101(10):1558-1563.
[26]Özdoğan, M., Wellmann, K., Paksuz, E., 2012. Effect of gossypol on blood serum parameters and small intestinal morphology of male broilers. J. Anim. Physiol. Anim. Nutr., 96(1):95-101.
[27]Park, J.A., Tirupathi Pichiah, P.B., Yu, J.J., et al., 2012. Anti-obesity effect of kimchi fermented with Weissella koreensis OK1-6 as starter in high-fat diet-induced obese C57BL/6J mice. J. Appl. Microbiol., 113(6):1507-1516.
[28]Patti, G.J., Yanes, O., Siuzdak, G., 2012. Innovation: metabolomics: the apogee of the omics trilogy. Nat. Rev. Mol. Cell Biol., 13(4):263-269.
[29]Pilvi, T.K., Seppänen-Laakso, T., Simolin, H., et al., 2008. Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction. Word J. Gastroenterol., 14(28):4462-4472.
[30]Shi, X., Xiao, C., Wang, Y., et al., 2013. Gallic acid intake induces alterations to systems metabolism in rats. J. Proteome Res., 12(2):991-1006.
[31]Sun, H., Tang, J.W., Yao, X.H., et al., 2012. Improvement of the nutritional quality of cottonseed meal by Bacillus subtilis and the addition of papain. Int. J. Agric. Biol., 14(4):987-993.
[32]Sun, H., Tang, J.W., Fang, C.L., et al., 2013. Molecular analysis of intestinal bacterial microbiota of broiler chickens fed diets containing fermented cottonseed meal. Poult. Sci., 92(2):392-401.
[33]Tang, J.W., Sun, H., Yao, X.H., et al., 2012. Effects of replacement of soybean meal by fermented cottonseed meal on growth performance, serum biochemical parameters and immune function of yellow-feathered broilers. Asian Australas. J. Anim. Sci., 25(3):393-400.
[34]Velagapudi, V.R., Hezaveh, R., Reigstad, C.S., et al., 2010. The gut microbiota modulates host energy and lipid metabolism in mice. J. Lipid Res., 51(5):1101-1112.
[35]Voshol, P.J., Jong, M.C., Dahlmans, V.E.H., et al., 2001. In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. Diabetes, 50(11):2585-2590.
[36]Wu, X.H., 2012. Effect and Regulation of Linseed Oil on Meat Quality and Fat Metabolism of Broilers. PhD Thesis, Univ. Northwest A & F, Yangling, China (in Chinese).
[37]Xiao, Y.P., Wu, T.X., Sun, J.M., et al., 2012. Response to dietary
[38]Yamamoto, M., Saleh, F., Tahir, M., et al., 2007. The effect of Koji-feed (fermented distillery by-product) on the growth performance and nutrient metabolizability in broiler. J. Poul. Sci., 44(3):291-296.
[39]Yang, L., Kasumov, T., Yu, L., et al., 2006. Metabolomic assays of the concentration and mass isotopomer distribution of gluconeogenic and citric acid cycle intermediates. Metabolomics, 2(2):85-94.
[40]Yang, X., Sun, J.Y., Guo, J.L., et al., 2012. Identification and proteomic analysis of a novel gossypol-degrading fungal strain. J. Sci. Food Agric., 92(4):943-951.
[41]Yin, Y.L., Zhong, H.Y., Huang, R.L., et al., 1993. Nutritive value of feedstuffs and diets for pigs: I. chemical composition, apparent ileal and fecal digestibility. Anim. Feed Sci. Tech., 44(1-2):1-27.
[42]Yin, Y.L., Chen, C.M., Zhong, H.Y., et al., 1994. Apparent digestibility of energy, cell wall constituents, crude protein and amino acids of the Chinese oil seed meals for growing pigs. Anim. Feed Sci. Tech., 45(3):283-298.
[43]Zhang, W.J., Xu, Z.R., Sun, J.Y., et al., 2006. Effect of selected fungi on the reduction of gossypol levels and nutritional value during solid substrate fermentation of cottonseed meal. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 7(9):690-695.
[44]Zhang, W.J., Xu, Z.R., Zhao, S.H., et al., 2007. Development of a microbial fermentation process for detoxification of gossypol in cottonseed meal. Anim. Feed Sci. Tech., 135(1-2):176-186.
[45]Zhao, S., Ma, H., Zou, S., et al., 2007. Effects of in ovo administration of DHEA on lipid metabolism and hepatic lipogenetic genes expression in broiler chickens during embryonic development. Lipids, 42(8):749-757.
[46]Zhao, X., Guo, Y., Guo, S., et al., 2013. Effects of Clostridium butyricum and Enterococcus faecium on growth performance, lipid metabolism, and cecal microbiota of broiler chickens. Appl. Microbiol. Biotechnol., 97(14):6477-6488.
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