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CLC number: S81

On-line Access: 2015-03-09

Received: 2014-09-24

Revision Accepted: 2015-02-08

Crosschecked: 2015-05-13

Cited: 2

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Citations:  Bibtex RefMan EndNote GB/T7714


Cun-xi Nie


Wen-ju Zhang


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.6 P.447-455


Tissue lipid metabolism and hepatic metabolomic profiling in response to supplementation of fermented cottonseed meal in the diets of broiler chickens

Author(s):  Cun-xi Nie, Wen-ju Zhang, Yan-feng Liu, Wen-xia Ge, Jian-cheng Liu

Affiliation(s):  College of Animal Science and Technology, Shihezi University, Shihezi 832003, China

Corresponding email(s):   zhangwj1022@sina.com

Key Words:  Fermented cottonseed meal, Lipid metabolism, Broiler, Gene expression, Metabolomics

Cun-xi Nie,Wen-ju Zhang,Yan-feng Liu,Wen-xia Ge,Jian-cheng Liu. Tissue lipid metabolism and hepatic metabolomic profiling in response to supplementation of fermented cottonseed meal in the diets of broiler chickens[J]. Journal of Zhejiang University Science B, 2015, 16(6): 447-455.

@article{title="Tissue lipid metabolism and hepatic metabolomic profiling in response to supplementation of fermented cottonseed meal in the diets of broiler chickens",
author="Cun-xi Nie,Wen-ju Zhang,Yan-feng Liu,Wen-xia Ge,Jian-cheng Liu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Tissue lipid metabolism and hepatic metabolomic profiling in response to supplementation of fermented cottonseed meal in the diets of broiler chickens
%A Cun-xi Nie
%A Wen-ju Zhang
%A Yan-feng Liu
%A Wen-xia Ge
%A Jian-cheng Liu
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 6
%P 447-455
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400255

T1 - Tissue lipid metabolism and hepatic metabolomic profiling in response to supplementation of fermented cottonseed meal in the diets of broiler chickens
A1 - Cun-xi Nie
A1 - Wen-ju Zhang
A1 - Yan-feng Liu
A1 - Wen-xia Ge
A1 - Jian-cheng Liu
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 6
SP - 447
EP - 455
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400255

This study investigated the effects of fermented cottonseed meal (FCSM) on lipid metabolites, lipid metabolism-related gene expression in liver tissues and abdominal adipose tissues, and hepatic metabolomic profiling in broiler chickens. One hundred and eighty 21-d-old broiler chickens were randomly divided into three diet groups with six replicates of 10 birds in each group. The three diets consisted of a control diet supplemented with unfermented cottonseed meal, an experimental diet of cottonseed meal fermented by Candida tropicalis, and a second experimental diet of cottonseed meal fermented by C. tropicalis plus Saccharomyces cerevisae. The results showed that FCSM intake significantly decreased the levels of abdominal fat and hepatic triglycerides (P<0.05 for both). Dietary FCSM supplementation down-regulated the mRNA expression of fatty acid synthase and acetyl CoA carboxylase in liver tissues and the lipoprotein lipase expression in abdominal fat tissues (P<0.05 for both). FCSM intake resulted in significant metabolic changes of multiple pathways in the liver involving the tricarboxylic acid cycle, synthesis of fatty acids, and the metabolism of glycerolipid and amino acids. These findings indicated that FCSM regulated lipid metabolism by increasing or decreasing the expression of the lipid-related gene and by altering multiple endogenous metabolites. lipid metabolism regulation is a complex process, this discovery provided new essential information about the effects of FCSM diets in broiler chickens and demonstrated the great potential of nutrimetabolomics in researching complex nutrients added to animal diets.




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