Full Text:   <934>

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CLC number: R394.6

On-line Access: 2015-07-03

Received: 2014-11-15

Revision Accepted: 2015-05-05

Crosschecked: 2015-06-16

Cited: 0

Clicked: 1482

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xin-yue Liu

http://orcid.org/0000-0002-5061-7477

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.7 P.632-639

http://doi.org/10.1631/jzus.B1400309


Correlation analysis of gene polymorphisms and β-lactam allergy


Author(s):  Jing Li, Xin-yue Liu, Lin-jing Li, Chong-ge You, Lei Shi, Shang-di Zhang, Qian Liu, Jun Wang, Ze-jing Liu, Ting-hong Lv

Affiliation(s):  Centre of Laboratory Medicine, Lanzhou University Second Hospital, Lanzhou 730030, China; more

Corresponding email(s):   liuxy@lzu.edu.cn

Key Words:  Allergy, β, -Lactam, Interleukin (IL), Pharmacogenomics, Single nucleotide polymorphism (SNP)


Jing Li, Xin-yue Liu, Lin-jing Li, Chong-ge You, Lei Shi, Shang-di Zhang, Qian Liu, Jun Wang, Ze-jing Liu, Ting-hong Lv. Correlation analysis of gene polymorphisms and β-lactam allergy[J]. Journal of Zhejiang University Science B, 2015, 16(7): 632-639.

@article{title="Correlation analysis of gene polymorphisms and β-lactam allergy",
author="Jing Li, Xin-yue Liu, Lin-jing Li, Chong-ge You, Lei Shi, Shang-di Zhang, Qian Liu, Jun Wang, Ze-jing Liu, Ting-hong Lv",
journal="Journal of Zhejiang University Science B",
volume="16",
number="7",
pages="632-639",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400309"
}

%0 Journal Article
%T Correlation analysis of gene polymorphisms and β-lactam allergy
%A Jing Li
%A Xin-yue Liu
%A Lin-jing Li
%A Chong-ge You
%A Lei Shi
%A Shang-di Zhang
%A Qian Liu
%A Jun Wang
%A Ze-jing Liu
%A Ting-hong Lv
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 7
%P 632-639
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400309

TY - JOUR
T1 - Correlation analysis of gene polymorphisms and β-lactam allergy
A1 - Jing Li
A1 - Xin-yue Liu
A1 - Lin-jing Li
A1 - Chong-ge You
A1 - Lei Shi
A1 - Shang-di Zhang
A1 - Qian Liu
A1 - Jun Wang
A1 - Ze-jing Liu
A1 - Ting-hong Lv
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 7
SP - 632
EP - 639
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400309


Abstract: 
A total of 64 patients with β;-Lactam allergy and 30 control subjects were enrolled in a case-control study. This study is aimed to analyze the relationship between β;-Lactam allergy and 10 single nucleotide polymorphisms (SNPs) in interleukin-10 (IL-10), IL-13, IL-4Rα, high-affinity immunoglobulin E-receptor β; chain (FcεRIβ;), interferon γ receptor 2 (IFNGR2), and CYP3A4, and within the Han Chinese population of Northwest China. Genotyping for the SNPs was conducted using the Sequenom MassARRAY® platform. SPSS 17.0 was employed to analyze the statistical data and SHEsis was used to perform the haplotype reconstruction and analyze linkage disequilibrium of SNPs of IL-10 and IL-13. The results showed that the genotype distribution of CYP3A4 rs2242480/CT differed significantly between case and control groups of males (P=0.022; odds ratio (OR)=0.167, 95% confidence interval (CI): 0.032–0.867). Further analysis showed that CCA, CCG, and TAA haplotypes of IL-10 had no significant correlation in patients with β;-Lactam allergy. The correlation between CCT and CAC haplotypes of IL-13 and β;-Lactam allergy needs to be further studied. The analysis did not reveal any differences in the distribution of others gene polymorphisms between cases and controls.

基因多态性与β-内酰胺类抗生素过敏的关联性分析

目的:探讨IL-10IL-13IL-4RαFcεRIβIFNGR2CYP3A4基因多态性与中国西北地区汉族人群β-内酰胺类抗生素过敏易感性的关联性。
创新点:首次在甘肃地区汉族人群中探讨10个单核苷酸多态性位点与β-内酰胺类抗生素过敏易感性的关联性,为该地区人群β-内酰胺类抗生素过敏患者提供了基因组学水平的诊断数据。
方法:以β-内酰胺类抗生素过敏者为研究对象进行病例对照研究,采用Sequenom MassARRAY®分子量阵列技术平台定制单核苷酸多态性(SNP)芯片检测10个单核苷酸多态性与甘肃地区汉族人群β-内酰胺类抗生素过敏易感性的关联性。应用SHEsis软件完成IL-10IL-13的连锁不平衡分析及单倍型构建。
结论:CYP3A4 rs2242480基因多态性与男性患者β-内酰胺类抗生素过敏有显著的相关性(P=0.022;OR=0.167,95% CI:0.032-0.867)。IL-13的CCT及CAC单倍型与中国西北地区汉族β-内酰胺类抗生素过敏的相关性有待进一步研究。

关键词:过敏;β-内酰胺类抗生素;白细胞介素;药物基因组学;单核苷酸多态性

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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