CLC number: R575
On-line Access: 2016-11-03
Received: 2016-03-03
Revision Accepted: 2016-05-14
Crosschecked: 2016-10-10
Cited: 6
Clicked: 6079
Yang Guo, Bo Chen, Li-jun Chen, Chun-feng Zhang, Charlie Xiang. Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis[J]. Journal of Zhejiang University Science B, 2016, 17(11): 831-841.
@article{title="Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis",
author="Yang Guo, Bo Chen, Li-jun Chen, Chun-feng Zhang, Charlie Xiang",
journal="Journal of Zhejiang University Science B",
volume="17",
number="11",
pages="831-841",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600101"
}
%0 Journal Article
%T Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis
%A Yang Guo
%A Bo Chen
%A Li-jun Chen
%A Chun-feng Zhang
%A Charlie Xiang
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 11
%P 831-841
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600101
TY - JOUR
T1 - Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis
A1 - Yang Guo
A1 - Bo Chen
A1 - Li-jun Chen
A1 - Chun-feng Zhang
A1 - Charlie Xiang
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 11
SP - 831
EP - 841
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600101
Abstract: liver fibrosis is the end-stage of many chronic liver diseases and is a significant health threat. The only effective therapy is liver transplantation, which still has many problems, including the lack of donor sources, immunological rejection, and high surgery costs, among others. However, the use of cell therapy is becoming more prevalent, and mesenchymal stem cells (MSCs) seem to be a promising cell type for the treatment of liver fibrosis. MSCs have multiple differentiation abilities, allowing them to migrate directly into injured tissue and differentiate into hepatocyte-like cells. Additionally, MSCs can release various growth factors and cytokines to increase hepatocyte regeneration, regress liver fibrosis, and regulate inflammation and immune responses. In this review, we summarize the current uses of MSC therapies for liver fibrosis and suggest potential future applications.
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