Full Text:   <874>

Summary:  <329>

CLC number: R28

On-line Access: 2017-04-05

Received: 2016-05-23

Revision Accepted: 2016-08-07

Crosschecked: 2017-03-17

Cited: 0

Clicked: 2126

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jian-mei Huang

http://orcid.org/0000-0002-5054-1011

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.4 P.343-352

http://doi.org/10.1631/jzus.B1600235


Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule


Author(s):  Huan-huan Pang, Meng-yi Li, Yuan Wang, Min-ke Tang, Chang-hua Ma, Jian-mei Huang

Affiliation(s):  School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 100102, China

Corresponding email(s):   huangjm@bucm.edu.cn

Key Words:  Fufang Xueshuantong, Panax notoginseng, Pharmacokinetics, Compatibility


Huan-huan Pang, Meng-yi Li, Yuan Wang, Min-ke Tang, Chang-hua Ma, Jian-mei Huang. Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule[J]. Journal of Zhejiang University Science B, 2017, 18(4): 343-352.

@article{title="Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule",
author="Huan-huan Pang, Meng-yi Li, Yuan Wang, Min-ke Tang, Chang-hua Ma, Jian-mei Huang",
journal="Journal of Zhejiang University Science B",
volume="18",
number="4",
pages="343-352",
year="2017",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600235"
}

%0 Journal Article
%T Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule
%A Huan-huan Pang
%A Meng-yi Li
%A Yuan Wang
%A Min-ke Tang
%A Chang-hua Ma
%A Jian-mei Huang
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 4
%P 343-352
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600235

TY - JOUR
T1 - Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule
A1 - Huan-huan Pang
A1 - Meng-yi Li
A1 - Yuan Wang
A1 - Min-ke Tang
A1 - Chang-hua Ma
A1 - Jian-mei Huang
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 4
SP - 343
EP - 352
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600235


Abstract: 
fufang Xueshuantong (FXT) is a well-known Chinese herbal formula which has been used to treat cardiovascular and ophthalmic diseases, especially diabetic retinopathy. Panax notoginseng (Burkill) F.H. Chen (PN) is the main herb of FXT, whose major bioactive constituents are ginsenosides. However, the scientific basis of the compatibility of FXT is still ambiguous. The present study investigated the scientific basis of the compatibility of FXT by comparing the pharmacokinetics of marker compounds after oral administrations of PN and FXT. A high performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed for simultaneous detection of notoginsenoside R1 (NR1), ginsenoside Rg1 (GRg1), and ginsenoside Rb1 (GRb1) in rat plasma. The pharmacokinetic studies of FXT and PN were performed using the established method with the pharmacokinetic parameters being determined by non-compartmental analysis. The results showed that the pharmacokinetic parameters (maximum concentration, area under the curve (AUC0–t), clearance, and mean residence time) of NR1, GRg1, and GRb1 were significantly different after oral administration of FXT (P<0.05) compared with PN. The AUC0–t values of GRg1 and GRb1 were 1.7- and 3.4-fold greater, respectively, in FXT than in PN. The compatible herbs of FXT could prolong the retention time and increase the systemic exposure of NR1, GRg1, and GRb1 compared with PN in vivo, providing some scientific basis for the compatibility and clinical use of FXT.

复方血栓通中多药配伍对君药三七有效成分药代动力学的影响

目的:通过比较君药三七和复方血栓通中有效成分的药代动力学,为复方血栓通的配伍和组方寻找科学依据。
创新点:首次为复方血栓通的组方合理性提供一定的科学依据。
方法:研究采用实验室前期建立的液相色谱-质联用方法同时测定大鼠血浆中的三七皂苷R1(NR1)、人参皂苷Rg1(GRg1)和人参皂苷Rb1(GRb1),对灌胃给予三七和复方血栓通胶囊后大鼠血浆中NR1、GRg1和GRb1的药代动力学参数进行测定。
结论:复方血栓通胶囊中除三七外的其他三味药的成分可以增加三七中NR1、GRg1和GRb1在大鼠体内的暴露水平,一定程度上揭示了复方血栓通全方配伍的合理性。

关键词:复方血栓通;三七;药代动力学;配伍

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Deng, G., Wang, D., Meng, M., et al., 2009. Simultaneous determination of notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and icariin in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. B, 877(22):2113-2122.

[2]Duan, H., Huang, J., Li, W., et al., 2013. Protective effects of Fufang Xueshuantong on diabetic retinopathy in rats. Evid.-Based. Compl. Alt., 2013:408268.

[3]Han, M., Fu, S., Fang, X.L., 2007. Comparison between the characteristics of absorption and pharmacokinetic behavior of ginsenoside Rg1 and ginsenoside Rb1 of Panax notoginseng saponins. Acta Pharmaceut. Sin., 42(8):849-853 (in Chinese).

[4]Hao, H., Lai, L., Zheng, C., et al., 2010. Microsomal cytochrome P450-mediated metabolism of protopanaxatriol ginsenosides: metabolite profile, reaction phenotyping, and structure-metabolism relationship. Drug Metab. Dispos., 38(10): 1731-1739.

[5]Huang, H., Yang, Y., Lv, C., et al., 2015. Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin pill following oral administration to mice. J. Ethnopharmacol., 161:175-185.

[6]Jian, W., Yu, S., Tang, M., et al., 2015. A combination of the main constituents of Fufang Xueshuantong Capsules shows protective effects against streptozotocin-induced retinal lesions in rats. J. Ethnopharmacol., 182:50-56.

[7]Lai, X., Zhang, L., Li, J., et al., 2011. Comparative pharmacokinetic and bioavailability studies of three salvianolic acids after the administration of Salviae miltiorrhizae alone or with synthetical borneol in rats. Fitoterapia, 82(6):883-888.

[8]Lau, C., Mooiman, K.D., Maas-Bakker, R.F., et al., 2013. Effect of Chinese herbs on CYP3A4 activity and expression in vitro. J. Ethnopharmacol., 149(2):543-549.

[9]Lennernas, H., Regardh, C., 1993. Evidence for an interaction between the β-blocker pafenolol and bile salts in the intestinal lumen of the rat leading to dose-dependent oral absorption and double peaks in the plasma concentration-time profile. Pharmaceut. Res., 10:819-883.

[10]Liu, R., Qin, M., Hang, P., et al., 2012. Effects of Panax notoginseng Saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo. Phytother. Res., 26(8):1113-1118.

[11]Long, W., Zhang, S., Wen, L., et al., 2014. In vivo distribution and pharmacokinetics of multiple active components from Danshen and Sanqi and their combination via inner ear administration. J. Ethnopharmacol., 156:199-208.

[12]National Pharmacopoeia Committee, 2015. Chinese Pharmacopoeia (2015 Chinese version) Part 1. China Medical Science Press, Beijing, p.1223-1224 (in Chinese).

[13]Ng, T.B., 2006. Pharmacological activity of sanchi ginseng (Panax notoginseng). J. Pharm. Pharmacol., 58(8):1007-1019.

[14]Oberle, R.L., Amidon, G.L., 1987. The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation for the double peak phenomenon. J. Pharmacokinet. Biop., 15(5):529-544.

[15]Pedersen, P.V., Miller, R., 1980. Pharmacokinetics and bioavailability of cimetidine in humans. J. Pharm. Sci., 69(4): 394-398.

[16]Sheng, S., Wang, J., Wang, L., et al., 2014. Network pharmacology analyses of the antithrombotic pharmacological mechanism of Fufang Xueshuantong Capsule with experimental support using disseminated intravascular coagulation rats. J. Ethnopharmacol., 154(3):735-744.

[17]Song, M., Hang, T.J., Zhang, Z.X., 2007. Pharmacokinetic interactions between the main components in the extracts of Salvia miltiorrhiza Bge. in rat. Acta Pharm. Sin., 42(3):301-307 (in Chinese).

[18]Wang, Q., Jiang, P., Ye, F., et al., 2014. Identification and pharmacokinetics of multiple constituents in rat plasma after oral administration of Yinchenzhufu decoction. J. Ethnopharmacol., 153(3):714-724.

[19]Wang, X., Yeung, J.H.K., 2010. Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats. J. Pharm. Pharmacol., 62(8):1077-1083.

[20]Wang, X., Yeung, J.H., 2012. Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture. Phytomedicine, 19(3-4):348-354.

[21]Wu, K., Wang, Z., Liu, D., et al., 2014. Pharmacokinetics, brain distribution, release and blood-brain barrier transport of Shunaoxin pills. J. Ethnopharmacol., 151(3):1133-1140.

[22]Xu, Q.F., Fang, X.L., Chen, D.F., 2003. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. J. Ethnopharmacol., 84(2-3):187-192.

[23]Yang, S., Zhang, K., Lin, X., et al., 2012. Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats. J. Pharmaceut. Biomed., 67-68:77-85.

[24]Yuan, Y., Yuan, F., Xu, Q., et al., 2011. Effect of Fufang Xueshuantong Capsule on a rat model of retinal vein occlusion. Chin. J. Integr. Med., 17(4):296-301.

[25]Zhang, Q., Xiao, X., Li, M., et al., 2013. Attenuating effect of Fufang Xueshuantong Capsule on kidney function in diabetic nephropathy model. J. Nat. Med., 67(1):86-97.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - Journal of Zhejiang University-SCIENCE