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Jian-mei Huang


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.4 P.343-352


Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule

Author(s):  Huan-huan Pang, Meng-yi Li, Yuan Wang, Min-ke Tang, Chang-hua Ma, Jian-mei Huang

Affiliation(s):  School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 100102, China

Corresponding email(s):   huangjm@bucm.edu.cn

Key Words:  Fufang Xueshuantong, Panax notoginseng, Pharmacokinetics, Compatibility

Huan-huan Pang, Meng-yi Li, Yuan Wang, Min-ke Tang, Chang-hua Ma, Jian-mei Huang. Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule[J]. Journal of Zhejiang University Science B, 2017, 18(4): 343-352.

@article{title="Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule",
author="Huan-huan Pang, Meng-yi Li, Yuan Wang, Min-ke Tang, Chang-hua Ma, Jian-mei Huang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule
%A Huan-huan Pang
%A Meng-yi Li
%A Yuan Wang
%A Min-ke Tang
%A Chang-hua Ma
%A Jian-mei Huang
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 4
%P 343-352
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600235

T1 - Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule
A1 - Huan-huan Pang
A1 - Meng-yi Li
A1 - Yuan Wang
A1 - Min-ke Tang
A1 - Chang-hua Ma
A1 - Jian-mei Huang
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 4
SP - 343
EP - 352
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600235

fufang Xueshuantong (FXT) is a well-known Chinese herbal formula which has been used to treat cardiovascular and ophthalmic diseases, especially diabetic retinopathy. Panax notoginseng (Burkill) F.H. Chen (PN) is the main herb of FXT, whose major bioactive constituents are ginsenosides. However, the scientific basis of the compatibility of FXT is still ambiguous. The present study investigated the scientific basis of the compatibility of FXT by comparing the pharmacokinetics of marker compounds after oral administrations of PN and FXT. A high performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed for simultaneous detection of notoginsenoside R1 (NR1), ginsenoside Rg1 (GRg1), and ginsenoside Rb1 (GRb1) in rat plasma. The pharmacokinetic studies of FXT and PN were performed using the established method with the pharmacokinetic parameters being determined by non-compartmental analysis. The results showed that the pharmacokinetic parameters (maximum concentration, area under the curve (AUC0–t), clearance, and mean residence time) of NR1, GRg1, and GRb1 were significantly different after oral administration of FXT (P<0.05) compared with PN. The AUC0–t values of GRg1 and GRb1 were 1.7- and 3.4-fold greater, respectively, in FXT than in PN. The compatible herbs of FXT could prolong the retention time and increase the systemic exposure of NR1, GRg1, and GRb1 compared with PN in vivo, providing some scientific basis for the compatibility and clinical use of FXT.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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