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CLC number: R764.35

On-line Access: 2019-01-22

Received: 2016-12-02

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Crosschecked: 2017-07-13

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yen-Fu Cheng

https://orcid.org/0000-0003-1995-5854

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.2 P.146-155

10.1631/jzus.B1600438


Atoh1 regulation in the cochlea: more than just transcription


Author(s):  Yen-Fu Cheng

Affiliation(s):  Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA; more

Corresponding email(s):   yfcheng2@vghtpe.gov.tw

Key Words:  Atoh1, Huwe1, Cochlea, Hair cells, Regeneration, Post-translational regulation


Yen-Fu Cheng. Atoh1 regulation in the cochlea: more than just transcription[J]. Journal of Zhejiang University Science B, 2019, 20(2): 146-155.

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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1600438


Abstract: 
More than 80% of all cases of deafness are related to the death or degeneration of cochlear hair cells and the associated spiral ganglion neurons, and a lack of regeneration of these cells leads to permanent hearing loss. Therefore, the regeneration of lost hair cells is an important goal for the treatment of deafness. atoh1 is a basic helix-loop-helix (bHLH) transcription factor that is critical in both the development and regeneration of cochlear hair cells. atoh1 is transcriptionally regulated by several signaling pathways, including Notch and Wnt signalings. At the post-translational level, it is regulated through the ubiquitin-proteasome pathway. In vitro and in vivo studies have revealed that manipulation of these signaling pathways not only controls development, but also leads to the regeneration of cochlear hair cells after damage. Recent progress toward understanding the signaling networks involved in hair cell development and regeneration has led to the development of new strategies to replace lost hair cells. This review focuses on our current understanding of the signaling pathways that regulate atoh1 in the cochlea.

Atoh1转录因子在耳蜗内的转译后调节

概要:Atoh1属于bHLH转录因子家族成员,其对耳蜗毛细胞的胚胎发育及损伤后再生具有重要作用.许多讯号通道在转录水平上对Atoh1有调节作用,包括Notch和Wnt通道.在蛋白转译后水平,Atoh1是经由泛素-蛋白酶通道所调节.体外细胞实验及体内动物实验都显示:经由上述讯号通道的调节手段不仅影响耳蜗发育,也导致毛细胞的损伤后再生.本综述回顾了耳蜗内各个对Atoh1调节讯号通道研究的进展,并聚焦于泛素-蛋白酶通道对Atoh1进行转译后调节及其对毛细胞发育的影响.

关键词:Atoh1;Huwe1;耳蜗;毛细胞;再生;转译后调节

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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