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Bin Wei


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.4 P.277-288


Immune response of T cells during herpes simplex virus type 1 (HSV-1) infection

Author(s):  Jie Zhang, Huan Liu, Bin Wei

Affiliation(s):  State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

Corresponding email(s):   weibin@wh.iov.cn

Key Words:  Herpes simplex virus type 1, Adaptive immunity, T cells, Vaccine

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Jie Zhang, Huan Liu, Bin Wei. Immune response of T cells during herpes simplex virus type 1 (HSV-1) infection[J]. Journal of Zhejiang University Science B, 2017, 18(1): 277-288.

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herpes simplex virus type 1 (HSV-1), a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life including fatal disseminated disease in newborns, cold sores, eye disease, and fatal encephalitis in adults. HSV-1 infection can trigger rapid immune responses, and efficient inhibition and clearance of HSV-1 infection rely on both the innate and adaptive immune responses of the host. Multiple strategies have been used to restrict host innate immune responses by HSV-1 to facilitate its infection in host cells. The adaptive immunity of the host plays an important role in inhibiting HSV-1 infections. The activation and regulation of t cells are the important aspects of the adaptive immunity. They play a crucial role in host-mediated immunity and are important for clearing HSV-1. In this review, we examine the findings on T cell immune responses during HSV-1 infection, which hold promise in the design of new vaccine candidates for HSV-1.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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